ALK (Anaplastic Lymphoma Receptor tyrosine Kinase, ALK)
Short Description: This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)\\/EML4 (chromosome 2), ALK\\/RANBP2 (chromosome 2), ALK\\/ATIC (chromosome 2), ALK\\/TFG (chromosome 3), ALK\\/NPM1 (chromosome 5), ALK\\/SQSTM1 (chromosome 5), ALK\\/KIF5B (chromosome 10), ALK\\/CLTC (chromosome 17), ALK\\/TPM4 (chromosome 19), and ALK\\/MSN (chromosome X).[provided by RefSeq, Jan 2011].
More information related to gene ALK.
More information related to gene ALK.
Products related to ALK Gene:
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1 results :
RNAi
ALK
Species: Human
HPLC purified
- Application:
- RNA Interference
- Gene:
- Anaplastic Lymphoma Receptor tyrosine Kinase
- Species:
- Human
- Purification:
- HPLC purified
Synonyms and alternative names related to ALK
- anaplastic lymphoma kinase (Alk)
- anaplastic lymphoma receptor tyrosine kinase (ALK)
- ALK receptor tyrosine kinase (ALK)
- ALK receptor tyrosine kinase (Alk)
- ALK
- CD246
- NBLST3
- Tcrz
Gene-IDs for different species
Protein level used designations for ALK
- ALK tyrosine kinase receptor
- anaplastic lymphoma kinase (Ki-1)
- CD246 antigen
- mutant anaplastic lymphoma kinase
- anaplastic lymphoma receptor tyrosine kinase
- anaplastic lymphoma kinase
Proteomics products related to ALK Gene
Other products related to ALK such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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