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MutaGEL® α1Antitrypsin S+Z allows the diagnosis of the "S" and "Z" mutations using two different PCR techniques unified in the kit MutaGEL®α1Antitrypsin S+Z: First, allel-specific primer pairs are used for identification of "S"-mutation site second, an RFLP (restriction length polymorphism) PCR-method is used for identification of the "Z" mutation. Result-interpretation is done by subsequent detection of generated DNA products/ fragments by gel-electrophoresis.