GNAS (GNAS Complex Locus, GNAS)
Short Description: This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012].
More information related to gene GNAS.
More information related to gene GNAS.
Products related to GNAS Gene:
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OriGene rr200464
ORF
PExp
Mammalian Expression Vector
pCMV6-Entry
Kanamycin
CMV Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- GNAS Complex Locus (GNAS)
- NCBI Accession:
- NM_001024823,NP_001019994
- Species:
- Rat
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-Entry
- Resistance Gene:
- Kanamycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN5349805
$737.55
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Will be delivered in 41 Business Days
OriGene rn200464
cDNA
PExp
Mammalian Expression Vector
pCMV6-Entry
Kanamycin
Enhanced CMV Promoter
unconjugated
Transient
1
- Type:
- cDNA
- Application:
- Protein Expression
- Gene:
- GNAS Complex Locus (GNAS)
- NCBI Accession:
- NM_001024823,NP_001019994
- Species:
- Rat
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-Entry
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Neomycin
- Promoter:
- Enhanced CMV Promoter
- Expression:
- Transient
Catalog No. ABIN3323759
$738.54
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Will be delivered in 41 Business Days
OriGene rc212804l2v
ORF
PExp
Lentiviral Vector
pLenti-C-mGFP
Chloramphenicol
CMV Promoter
GFP tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- GNAS Complex Locus (GNAS)
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-C-mGFP
- Resistance Gene:
- Chloramphenicol
- Promoter:
- CMV Promoter
- Fusion Tag:
- GFP tag
- Expression:
- Transient
Catalog No. ABIN6412663
$841.50
Plus shipping costs $50.00, if applicable $20.00 dry ice
200 μL
Shipping to:
United States
Delivery in 21 to 26 Business Days
OriGene rc212804l1v
ORF
PExp
Lentiviral Vector
pLenti-C-Myc-DDK
Chloramphenicol
CMV Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- GNAS Complex Locus (GNAS)
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-C-Myc-DDK
- Resistance Gene:
- Chloramphenicol
- Promoter:
- CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN6412662
$841.50
Plus shipping costs $50.00, if applicable $20.00 dry ice
200 μL
Shipping to:
United States
Delivery in 21 to 26 Business Days
OriGene tg304299
shRNA
RNAi
Retroviral Vector
pGFP-V-RS
Kanamycin
U6 Promoter
GFP tag
Transient
1
- Type:
- shRNA
- Application:
- RNA Interference
- Gene:
- GNAS Complex Locus (GNAS)
- Species:
- Human
- Vector type:
- Retroviral Vector
- Vector backbone:
- pGFP-V-RS
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter
- Fusion Tag:
- GFP tag
- Expression:
- Transient, Stable
Catalog No. ABIN3729206
$874.17
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 4 to 8 Business Days
OriGene tr304299
shRNA
RNAi
Retroviral Vector
pRS
Ampicillin
U6 Promoter
unconjugated
Transient
1
- Type:
- shRNA
- Application:
- RNA Interference
- Gene:
- GNAS Complex Locus (GNAS)
- Species:
- Human
- Vector type:
- Retroviral Vector
- Vector backbone:
- pRS
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter
- Expression:
- Transient, Stable
Catalog No. ABIN3769883
$874.17
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 4 to 8 Business Days
OriGene tr500832
shRNA
RNAi
Retroviral Vector
pRS
Ampicillin
U6 Promoter
unconjugated
Transient
1
- Type:
- shRNA
- Application:
- RNA Interference
- Gene:
- GNAS Complex Locus (GNAS)
- Species:
- Mouse
- Vector type:
- Retroviral Vector
- Vector backbone:
- pRS
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter
- Expression:
- Transient, Stable
Catalog No. ABIN3533179
$874.17
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Will be delivered in 16 Business Days
OriGene tr710532
shRNA
RNAi
Retroviral Vector
pRS
Ampicillin
U6 Promoter
unconjugated
Transient
1
- Type:
- shRNA
- Application:
- RNA Interference
- Gene:
- GNAS Complex Locus (GNAS)
- Species:
- Rat
- Vector type:
- Retroviral Vector
- Vector backbone:
- pRS
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter
- Expression:
- Transient, Stable
Catalog No. ABIN3435421
$874.17
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Will be delivered in 16 Business Days
OriGene mc222309
cDNA
PExp
Mammalian Expression Vector
pCMV6-Entry
Kanamycin
Enhanced CMV Promoter
unconjugated
Transient
1
- Type:
- cDNA
- Application:
- Protein Expression
- Gene:
- GNAS Complex Locus (GNAS)
- NCBI Accession:
- NM_201617,NP_963911
- Species:
- Mouse
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-Entry
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Neomycin
- Promoter:
- Enhanced CMV Promoter
- Expression:
- Transient
Catalog No. ABIN3323757
$874.17
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Will be delivered in 41 Business Days
OriGene rg222992
ORF
PExp
Mammalian Expression Vector
pCMV6-AC-GFP
Ampicillin
CMV Promoter
GFP tag
Stable
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- GNAS Complex Locus (GNAS)
- NCBI Accession:
- NM_001077488,NP_001070956
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-AC-GFP
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- GFP tag
- Expression:
- Stable, Transient
Catalog No. ABIN5349797
$877.14
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Will be delivered in 21 Business Days
Synonyms and alternative names related to GNAS
- GNAS complex locus (GNAS)
- guanine nucleotide-binding protein G(s) subunit alpha (LOC694289)
- guanine nucleotide-binding protein G(s) subunit alpha (LOC469986)
- GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus (Gnas)
- GNAS complex locus S homeolog (gnas.S)
- GNAS complex locus (Gnas)
- GNAS complex locus (gnas)
- neuroendocrine secretory protein 55-like (LOC100346323)
- guanine nucleotide-binding protein G(s) subunit alpha (LOC100442753)
- guanine nucleotide-binding protein G(s) subunit alpha (LOC100732436)
- 5530400H20Rik
- A930027G11Rik
- AHO
- C20orf45
- C130027O20Rik
- G-alpha-S
- G-alpha-s
- Galphas
- gnal
- GNAS
- Gnas
- gnas-a
- GNAS1
- Gnas1
- Gnasxl
- Gnpas
- GPSA
- GSA
- Gsa
- GSP
- NESP
- Nesp
- Nesp55
- Nespl
- Oed-Sml
- Oedsml
- P1
- P2
- P3
- PHP1A
- PHP1B
- PHP1C
- POH
- PORGSA1
Gene-IDs for different species
Protein level used designations for GNAS
- adenylate cyclase-stimulating G alpha protein
- alternative gene product encoded by XL-exon
- extra large alphas protein
- guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1
- guanine nucleotide regulatory protein
- guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
- neuroendocrine secretory protein
- protein ALEX
- secretogranin VI
- GNAS complex locus
- GTP-binding regulatory protein alpha subunit exon 1
- guanine nucleotide binding protein, alpha stimulating activity polypeptide 1
- guanine nucleotide-binding protein G(s) subunit alpha
- stimulatory GTP binding protein
- alpha-stimulatory subunit of GTP-binding protein
- guanine nucleotide-binding protein, alpha-stimulating activity polypeptide 1
- Gs alpha subunit
- neuroendocrine secretory protein 55
- stimulatory G-protein alpha subunit
- guanine nucleotide-binding protein G(s) subunit alpha isoforms
- G-alpha-8
- GNAS
- GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
- guanine nucleotide binding protein alpha s
- guanine nucleotide-binding protein G-s, alpha subunit
- guanine nucleotide binding protein, alpha stimulating, olfactory type
- guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like
- Galpha s
Proteomics products related to GNAS Gene
Other products related to GNAS such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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