A short hairpin RNA or small hairpin RNA (shRNA) is an artificial RNA molecule with a tight hairpin turn that can be used to silence target gene expression via RNA interference (RNAi).
Expression of shRNA in cells is typically accomplished by delivery of plasmids or through viral or bacterial vectors. Using shRNA over RNAi yields several advantages: 99% of RNAi is degraded after 48 hours; integrated shRNA can be expressed for up to 3 years. Additionally the likelihood of specific “off target” effects is much lower using shRNA.
To perform your desired knockdown experiment browse our products at genomics-online and choose between our viral vectors and different fusion tags like GFP and RFP. For more detailed information regarding a product please download the datasheet. If you need help with finding the right kit, our customer support will gladly help you via live chat, email or phone.