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PRMT5 (Protein Arginine Methyltransferase 5, PRMT5)

Short Description: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3)\; such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR\; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation. Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (By similarity). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation (By similarity). Methylates HOXA9 (By similarity).
More information related to gene PRMT5.

Products related to PRMT5 Gene:

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73 results

Human PRMT5 ORF Clone in Lentiviral Vector (Myc-DYKDDDDK Tag)
OriGene rc203458l1 ORF PExp Lentiviral Vector pLenti-C-Myc-DDK Chloramphenicol CMV Promoter Myc-DYKDDDDK Tag Transient
Type:
ORF
Application:
Protein Expression
Gene:
Protein Arginine Methyltransferase 5 (PRMT5)
NCBI Accession:
NM_006109,NP_006100
Species:
Human
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-C-Myc-DDK
Resistance Gene:
Chloramphenicol
Promoter:
CMV Promoter
Fusion Tag:
Myc-DYKDDDDK Tag
Expression:
Transient
Catalog No. ABIN5385727
$884.07
Plus shipping costs $50.00
10 μg
Shipping to: United States
Delivery in 8 to 11 Business Days
Details
Details
Human PRMT5 ORF Clone in Lentiviral Vector (GFP tag)
OriGene rc203458l2 ORF PExp Lentiviral Vector pLenti-C-mGFP Chloramphenicol CMV Promoter GFP tag Transient
Type:
ORF
Application:
Protein Expression
Gene:
Protein Arginine Methyltransferase 5 (PRMT5)
NCBI Accession:
NM_006109,NP_006100
Species:
Human
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-C-mGFP
Resistance Gene:
Chloramphenicol
Promoter:
CMV Promoter
Fusion Tag:
GFP tag
Expression:
Transient
Catalog No. ABIN5385724
$884.07
Plus shipping costs $50.00
10 μg
Shipping to: United States
Delivery in 21 to 22 Business Days
Details
Details
Human PRMT5 ORF Clone in Mammalian Expression Vector (Myc-DYKDDDDK Tag)
OriGene rc238393 ORF PExp Mammalian Expression Vector pCMV6-Entry Kanamycin CMV Promoter Myc-DYKDDDDK Tag Transient
Type:
ORF
Application:
Protein Expression
Gene:
Protein Arginine Methyltransferase 5 (PRMT5)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pCMV6-Entry
Resistance Gene:
Kanamycin
Promoter:
CMV Promoter
Fusion Tag:
Myc-DYKDDDDK Tag
Expression:
Transient
Catalog No. ABIN5385719
$497.97
Plus shipping costs $50.00
10 μg
Shipping to: United States
Delivery in 16 to 17 Business Days
Details
Details
Human PRMT5 ORF Clone in Mammalian Expression Vector (Myc-DYKDDDDK Tag)
OriGene rc239021 ORF PExp Mammalian Expression Vector pCMV6-Entry Kanamycin CMV Promoter Myc-DYKDDDDK Tag Transient
Type:
ORF
Application:
Protein Expression
Gene:
Protein Arginine Methyltransferase 5 (PRMT5)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pCMV6-Entry
Resistance Gene:
Kanamycin
Promoter:
CMV Promoter
Fusion Tag:
Myc-DYKDDDDK Tag
Expression:
Transient
Catalog No. ABIN5385722
$819.72
Plus shipping costs $50.00
10 μg
Shipping to: United States
Delivery in 21 to 22 Business Days
Details
Details
Rat PRMT5 ORF Clone in Mammalian Expression Vector (Myc-DYKDDDDK Tag)
OriGene rr205792 ORF PExp Mammalian Expression Vector pCMV6-Entry Kanamycin CMV Promoter Myc-DYKDDDDK Tag Transient
Type:
ORF
Application:
Protein Expression
Gene:
Protein Arginine Methyltransferase 5 (PRMT5)
NCBI Accession:
NM_001108867,NP_001102337
Species:
Rat
Vector type:
Mammalian Expression Vector
Vector backbone:
pCMV6-Entry
Resistance Gene:
Kanamycin
Promoter:
CMV Promoter
Fusion Tag:
Myc-DYKDDDDK Tag
Expression:
Transient
Catalog No. ABIN5385723
$645.48
Plus shipping costs $50.00
10 μg
Shipping to: United States
Delivery in 21 to 22 Business Days
Details
Details
Human PRMT5 ORF Clone in Lentiviral Vector (GFP tag)
OriGene rc223791l2 ORF PExp Lentiviral Vector pLenti-C-mGFP Chloramphenicol CMV Promoter GFP tag Transient
Type:
ORF
Application:
Protein Expression
Gene:
Protein Arginine Methyltransferase 5 (PRMT5)
NCBI Accession:
NM_001039619,NP_001034708
Species:
Human
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-C-mGFP
Resistance Gene:
Chloramphenicol
Promoter:
CMV Promoter
Fusion Tag:
GFP tag
Expression:
Transient
Catalog No. ABIN5385725
$868.23
Plus shipping costs $50.00
10 μg
Shipping to: United States
Delivery in 21 to 22 Business Days
Details
Details
Human PRMT5 ORF Clone in Lentiviral Vector (Myc-DYKDDDDK Tag)
OriGene rc223791l1 ORF PExp Lentiviral Vector pLenti-C-Myc-DDK Chloramphenicol CMV Promoter Myc-DYKDDDDK Tag Transient
Type:
ORF
Application:
Protein Expression
Gene:
Protein Arginine Methyltransferase 5 (PRMT5)
NCBI Accession:
NM_001039619,NP_001034708
Species:
Human
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-C-Myc-DDK
Resistance Gene:
Chloramphenicol
Promoter:
CMV Promoter
Fusion Tag:
Myc-DYKDDDDK Tag
Expression:
Transient
Catalog No. ABIN5385728
$868.23
Plus shipping costs $50.00
10 μg
Shipping to: United States
Delivery in 21 to 22 Business Days
Details
Details
Human PRMT5 ORF Clone in Mammalian Expression Vector (DYKDDDDK Tag)
ORF PExp Mammalian Expression Vector pcDNA3.1+C-(K)-DYK Ampicillin CMV Promoter DYKDDDDK Tag Transient
ISO 9001:2008
Type:
ORF
Application:
Protein Expression
Gene:
Protein Arginine Methyltransferase 5 (PRMT5)
NCBI Accession:
NM_001282953
Gene ID:
10419 (Human, PRMT5)
Vector type:
Mammalian Expression Vector
Vector backbone:
pcDNA3.1+C-(K)-DYK
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
DYKDDDDK Tag
Expression:
Transient, Stable
Catalog No. ABIN4925027
$439.00
Plus shipping costs $50.00
10 μg
Shipping to: United States
Delivery in 6 to 9 Business Days
Details
Details
Human PRMT5 ORF Clone in Mammalian Expression Vector (DYKDDDDK Tag)
ORF PExp Mammalian Expression Vector pcDNA3.1+C-(K)-DYK Ampicillin CMV Promoter DYKDDDDK Tag Transient
ISO 9001:2008
Type:
ORF
Application:
Protein Expression
Gene:
Protein Arginine Methyltransferase 5 (PRMT5)
NCBI Accession:
NM_001282955
Gene ID:
10419 (Human, PRMT5)
Vector type:
Mammalian Expression Vector
Vector backbone:
pcDNA3.1+C-(K)-DYK
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
DYKDDDDK Tag
Expression:
Transient, Stable
Catalog No. ABIN4925028
$439.00
Plus shipping costs $50.00
10 μg
Shipping to: United States
Delivery in 6 to 9 Business Days
Details
Details
Human PRMT5 ORF Clone in Mammalian Expression Vector (DYKDDDDK Tag)
ORF PExp Mammalian Expression Vector pcDNA3.1+C-(K)-DYK Ampicillin CMV Promoter DYKDDDDK Tag Transient
ISO 9001:2008
Type:
ORF
Application:
Protein Expression
Gene:
Protein Arginine Methyltransferase 5 (PRMT5)
NCBI Accession:
NM_001282956
Gene ID:
10419 (Human, PRMT5)
Vector type:
Mammalian Expression Vector
Vector backbone:
pcDNA3.1+C-(K)-DYK
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
DYKDDDDK Tag
Expression:
Transient, Stable
Catalog No. ABIN4925029
$319.00
Plus shipping costs $50.00
10 μg
Shipping to: United States
Delivery in 6 to 9 Business Days
Details
Details
  • Type
    • Plasmid
    • Primer
  • Supplier
    • OriGene
    • antibodies-online
    • GenScript
  • Reactivity
    • Human
    • Rat
    • Mouse
  • Cited in publications
  • Application
    • Protein Expression (PExp)
    • Genome Editing with Engineered Nucleases (GEEN)
    • RNA Interference (RNAi)
    • Cloning (Clon)
  • Conjugate
    • Un-conjugated
    • Myc-DYKDDDDK Tag
    • GFP tag
    • DYKDDDDK Tag
    • His tag
    • HA tag
    • His-GST
    • His-MBP
    • RFP tag
  • Vector Backbone
    • pCMV6-Entry
    • pLenti-U6-sgRNA-PGK-Neo
    • pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
    • pcDNA3.1+C-(K)-DYK
    • pGFP-C-shLenti
    • pGFP-V-RS
    • pLenti-C-Myc-DDK
    • pLenti-C-mGFP
    • pORF
    • pPB-His-GST
    • pPB-His-MBP
    • pPB-N-His
    • pPM-C-HA
    • pPM-C-His
    • pRS
    • pCMV6-AC-GFP
    • pCMV6-XL5
    • pCas-Guide
    • pRFP-C-RS
  • Vector
    • Mammalian Expression Vector
    • Lentiviral Vector
    • Bacterial Expression Vector
    • Retroviral Vector
    • Cloning Vector
  • Insert
    • ORF
    • cDNA
    • shRNA
    • gRNA + Cas9
    • gRNA
  • Type of Oligonucleotide
    • siRNA Oligo
  • Bacterial Resistance
    • Kanamycin
    • Ampicillin
    • Chloramphenicol
    • Spectinomycin
  • Expression Type
    • Transient
    • Stable
  • Selectable Marker
    • Neomycin
    • Puromycin
  • Promoter
    • CMV Promoter
    • U6 Promoter
    • T7 Promoter
    • Enhanced CMV Promoter
    • PGK Promoter
    • SFFV Promoter
  • Format
    • Lyophilized
    • Liquid
    • Viral Particles

Synonyms and alternative names related to PRMT5

  • protein arginine methyltransferase 5 (PRMT5)
  • protein arginine N-methyltransferase 5 (Prmt5)
  • protein arginine methyltransferase 5 (Prmt5)
  • protein arginine methyltransferase 5 (prmt5)
  • protein arginine methyltransferase 5 L homeolog (prmt5.L)
  • putative arginine N-methyltransferase, type II (PRMT5)
  • Skb1 family protein (prmt5)
  • protein arginine N-methyltransferase 5 (LOC100115766)
  • Protein arginine N-methyltransferase 5 (prmt-5)
  • DDBDRAFT_0187422
  • DDBDRAFT_0235403
  • DDB_0187422
  • DDB_0235403
  • HRMT1L5
  • hrmt1l5
  • hsl7
  • IBP72
  • ibp72
  • JBP1
  • Jbp1
  • jbp1
  • NV18830
  • si:zc14a17.2
  • SKB1
  • Skb1
  • skb1
  • SKB1Hs
  • skb1hs
  • wu:fb95f10
  • zgc:110669

Gene-IDs for different species

Protein level used designations for PRMT5

  • 72 kDa ICln-binding protein
  • HMT1 hnRNP methyltransferase-like 5
  • SKB1 homolog
  • histone-arginine N-methyltransferase PRMT5
  • jak-binding protein 1
  • protein arginine N-methyltransferase 5
  • shk1 kinase-binding protein 1 homolog
  • protein arginine methyltransferase 5
  • Jak-binding protein 1
  • putative arginine N-methyltransferase, type II
  • protein arginine methyltransferase
  • protein arginine N-methyltransferase 5-like
Other products related to PRMT5 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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