Human OLR1 cDNA Clone in Mammalian Expression Vector
This is a Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 plasmid from OriGene - 4 times cited - with cDNA insert cloned into Mammalian Expression VectorpCMV6-XL5. Insert length: 2600 bp. Transient expression. Suitable for PExp.
Bacterial selection: Ampicillin.
1 image
(4 references)
Catalog No. ABIN3385597
Supplier Product No.: sc118589
$297.00
Plus shipping costs $50.00
10 μg
Shipping to:
United States
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Quick Overview for Human OLR1 cDNA Clone in Mammalian Expression Vector (ABIN3385597)
Gene
OLR1
(Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))
Application
Protein Expression (PExp)
Insert
cDNA
Vector
Mammalian Expression Vector
Vector Backbone
pCMV6-XL5
Promoter
Enhanced CMV Promoter, T7 Promoter
Bacterial Resistance
Ampicillin
Expression Type
Transient
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Species
- Human
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Supplier Product No.
- sc118589
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Supplier
- OriGene
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Purpose
- Untagged full-length cDNA clone from Human OLR1 is ideal for over-expression of native protein for functional studies.
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Specificity
- Restriction Site: NotI-NotI
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Characteristics
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- These cDNA clones are isolated from full-length cDNA libraries and usually contain the coding sequence as well as the untranslated regions (UTRs) of the mRNA transcript appropriate to the library from which they were isolated.
- These cDNA clones are ideal for over-expression of native proteins for functional studies. Provided as 10 μg transfection-ready plasmids.
- Every lot of primer is tested to provide clean sequencing of cDNA clones.
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Purification
- The DNAs were purified using PowerPrep HP Plasmid isolation kits for transfection ready plasmids.
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Components
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- The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA.
- The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials.
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Insert Length
- 2600 bp
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Sequencing Primer
- VP1.5 (forward) 5'GGACTTTCCAAAATGTCG 3', XL39 (reverse) 5'ATTAGGACAAGGCTGGTGGG 3'
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Storage
- RT,-20 °C
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Storage Comment
- The lyophilized plasmid is stable for up to one year when stored at ambient temperature. Following dissolution in 100 μL dH2O, store at -20 °C. Lyophilized primers are stable for up to one year when stored at ambient temperature. Following dissolution in 10 μL dH2O, store at -20 °C.
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Expiry Date
- 12 months
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: "High-Density Lipoprotein Prevents Endoplasmic Reticulum Stress-Induced Downregulation of Liver LOX-1 Expression." in: PLoS ONE, Vol. 10, Issue 4, pp. e0124285, (2015) (PubMed).
: "Prevention of export of anoxia/reoxygenation injury from ischemic to nonischemic cardiomyocytes via inhibition of endocytosis." in: American journal of physiology. Heart and circulatory physiology, Vol. 306, Issue 12, pp. H1700-7, (2014) (PubMed).
: "CRP is a novel ligand for the oxidized LDL receptor LOX-1." in: American journal of physiology. Heart and circulatory physiology, Vol. 296, Issue 5, pp. H1643-50, (2009) (PubMed).
: "LOX-1-dependent transcriptional regulation in response to oxidized LDL treatment of human aortic endothelial cells." in: American journal of physiology. Cell physiology, Vol. 296, Issue 6, pp. C1329-37, (2009) (PubMed).
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- OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))
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Alternative Name
- OLR1
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Background
- This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010].Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
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NCBI Accession
- NM_002543, NP_002534
Target
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