Human CCR3 cDNA Clone in Mammalian Expression Vector
This is a Chemokine (C-C Motif) Receptor 3 plasmid from OriGene - one-time cited - with cDNA insert cloned into Mammalian Expression VectorpCMV6-XL5. Insert length: 2030 bp. Transient expression. Suitable for PExp.
Bacterial selection: Ampicillin.
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(1 reference)
Catalog No. ABIN3388807
Supplier Product No.: sc123356
$452.43
Plus shipping costs $50.00
10 μg
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Quick Overview for Human CCR3 cDNA Clone in Mammalian Expression Vector (ABIN3388807)
Gene
CCR3
(Chemokine (C-C Motif) Receptor 3 (CCR3))
Application
Protein Expression (PExp)
Insert
cDNA
Vector
Mammalian Expression Vector
Vector Backbone
pCMV6-XL5
Promoter
Enhanced CMV Promoter, T7 Promoter
Bacterial Resistance
Ampicillin
Expression Type
Transient
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Species
- Human
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Supplier Product No.
- sc123356
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Supplier
- OriGene
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Purpose
- Untagged full-length cDNA clone from Human CCR3 is ideal for over-expression of native protein for functional studies.
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Characteristics
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- These cDNA clones are isolated from full-length cDNA libraries and usually contain the coding sequence as well as the untranslated regions (UTRs) of the mRNA transcript appropriate to the library from which they were isolated.
- These cDNA clones are ideal for over-expression of native proteins for functional studies. Provided as 10 μg transfection-ready plasmids.
- Every lot of primer is tested to provide clean sequencing of cDNA clones.
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Purification
- The DNAs were purified using PowerPrep HP Plasmid isolation kits for transfection ready plasmids.
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Components
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- The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA.
- The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials.
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Insert Length
- 2030 bp
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Sequencing Primer
- VP1.5 (forward) 5'GGACTTTCCAAAATGTCG 3', XL39 (reverse) 5'ATTAGGACAAGGCTGGTGGG 3'
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Storage
- RT,-20 °C
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Storage Comment
- The lyophilized plasmid is stable for up to one year when stored at ambient temperature. Following dissolution in 100 μL dH2O, store at -20 °C. Lyophilized primers are stable for up to one year when stored at ambient temperature. Following dissolution in 10 μL dH2O, store at -20 °C.
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Expiry Date
- 12 months
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: "Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8." in: Molecular pharmacology, Vol. 72, Issue 2, pp. 327-40, (2007) (PubMed).
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: "Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8." in: Molecular pharmacology, Vol. 72, Issue 2, pp. 327-40, (2007) (PubMed).
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- CCR3 (Chemokine (C-C Motif) Receptor 3 (CCR3))
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Alternative Name
- CCR3
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Background
- The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009].Transcript Variant: This variant (2) lacks an internal exon in the 5' UTR, as compared to variant 1. Both variants encode the same isoform 1.
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NCBI Accession
- NM_178329, NP_847899
Target
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