Human DSG1 ORF Clone in Mammalian Expression Vector (Myc-DYKDDDDK Tag)
ORF
PExp
Mammalian Expression Vector
pCMV6-Entry
Kanamycin
CMV Promoter
Myc-DYKDDDDK Tag
Transient
Catalog No. ABIN5345034
Quick Overview for Human DSG1 ORF Clone in Mammalian Expression Vector (Myc-DYKDDDDK Tag) (ABIN5345034)
Gene
Desmoglein 1 (DSG1)
Fusion tag
Myc-DYKDDDDK Tag
Application
Protein Expression (PExp)
Insert
ORF
Vector
Mammalian Expression Vector
Vector Backbone
pCMV6-Entry
Promoter
CMV Promoter
Bacterial Resistance
Kanamycin
Expression Type
Transient
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Species
- Human
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Purpose
- Mammalian Vector with ORF clone of Human desmoglein 1 (DSG1)
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Specificity
- Restriction Site: SgfI-MluI
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Grade
- End-sequenced
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Components
- The ORF clone is ion-exchange column purified, transfection-ready dried plasmid DNA, and shipped with 2 vector sequencing primers.
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Insert Length
- 3150 bp
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Sequencing Primer
- VP1.5 (forward) 5'GGACTTTCCAAAATGTCG 3', XL39 (reverse) 5'ATTAGGACAAGGCTGGTGGG 3'
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Storage
- 4 °C/-20 °C
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- Desmoglein 1 (DSG1)
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Background
- This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma.
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NCBI Accession
- NM_001942, NP_001933
Target
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