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Casilio HDR

Genomics-online offers plasmids for HDR (homology directed repair) mediated gene editing. HDR-mediated gene editing can be applied for the gene knock-out, correction of point mutations and introduction of beneficial mutations. Our plasmids use the Casilio system which combines CRISPR/dCas9 with a Pumilio RNA-binding domain to increase specificity. The Pumilio binding site (PBS) recruits RNA-binding protein-tethered DNA repair proteins (DRP) to target site via aptamers appended to guide RNA. Casilio enables multimerization of multiple DRP. This minimizes errors in DNA repair, a crucial factor in in possible fields of application such as gene therapy.

dCas9E1E2E4E3sgRNA
Fig.1: Multimerization in the Casilio HDR system .

11 results :

Casilio HDR EpEd Mammalian Expression Vector pmax-CtIP(T847E)_53BP1 Kanamycin CMV Promoter unconjugated Transient
Type:
Casilio HDR
Application:
Epigenetic Editing
Gene:
CtIP(T847E)_53BP1
Species:
Various Species
Vector type:
Mammalian Expression Vector
Vector backbone:
pmax-CtIP(T847E)_53BP1
Resistance Gene:
Kanamycin
Promoter:
CMV Promoter
Expression:
Transient
Catalog No. ABIN7536613
Casilio HDR EpEd Mammalian Expression Vector pmax-Cas9 Kanamycin CMV Promoter unconjugated Transient
Type:
Casilio HDR
Application:
Epigenetic Editing
Gene:
CRISPR-Cas9
Species:
Various Species
Vector type:
Mammalian Expression Vector
Vector backbone:
pmax-Cas9
Resistance Gene:
Kanamycin
Promoter:
CMV Promoter
Expression:
Transient
Catalog No. ABIN7536612
Casilio HDR EpEd Mammalian Expression Vector pmax-FANCF_PUFa Kanamycin CMV Promoter unconjugated Transient
Type:
Casilio HDR
Application:
Epigenetic Editing
Gene:
FANCF_PUFa
Species:
Various Species
Vector type:
Mammalian Expression Vector
Vector backbone:
pmax-FANCF_PUFa
Resistance Gene:
Kanamycin
Promoter:
CMV Promoter
Expression:
Transient
Catalog No. ABIN7536611
Casilio HDR EpEd Mammalian Expression Vector pmax-XRCC3_PUFa Kanamycin CMV Promoter unconjugated Transient
Type:
Casilio HDR
Application:
Epigenetic Editing
Gene:
XRCC3_PUFa
Species:
Various Species
Vector type:
Mammalian Expression Vector
Vector backbone:
pmax-XRCC3_PUFa
Resistance Gene:
Kanamycin
Promoter:
CMV Promoter
Expression:
Transient
Catalog No. ABIN7536609
Casilio HDR EpEd Mammalian Expression Vector pmax-BRCA1_PUFa Kanamycin CMV Promoter unconjugated Transient
Type:
Casilio HDR
Application:
Epigenetic Editing
Gene:
BRCA1_PUFa
Species:
Various Species
Vector type:
Mammalian Expression Vector
Vector backbone:
pmax-BRCA1_PUFa
Resistance Gene:
Kanamycin
Promoter:
CMV Promoter
Expression:
Transient
Catalog No. ABIN7536610
Casilio HDR EpEd Mammalian Expression Vector pCR8-sgFE-EMX1-5xPBSa Spectinomycin U6 Promoter unconjugated Transient
Type:
Casilio HDR
Application:
Epigenetic Editing
Gene:
SgFE-EMX1-5xPBSa
Species:
Various Species
Vector type:
Mammalian Expression Vector
Vector backbone:
pCR8-sgFE-EMX1-5xPBSa
Resistance Gene:
Spectinomycin
Promoter:
U6 Promoter
Expression:
Transient
Catalog No. ABIN7536618
Casilio HDR EpEd Mammalian Expression Vector pmax-CtIP(T847E)_PUFa Kanamycin CMV Promoter unconjugated Transient
Type:
Casilio HDR
Application:
Epigenetic Editing
Gene:
CtIP(T847E)_PUFa
Species:
Various Species
Vector type:
Mammalian Expression Vector
Vector backbone:
pmaxCtIP(T847E)_PUFa
Resistance Gene:
Kanamycin
Promoter:
CMV Promoter
Expression:
Transient
Catalog No. ABIN7536617
Casilio HDR EpEd Mammalian Expression Vector pmax-XRCC3_53BP1 Kanamycin CMV Promoter unconjugated Transient
Type:
Casilio HDR
Application:
Epigenetic Editing
Gene:
XRCC3_53BP1
Species:
Various Species
Vector type:
Mammalian Expression Vector
Vector backbone:
pmax-XRCC3_53BP1
Resistance Gene:
Kanamycin
Promoter:
CMV Promoter
Expression:
Transient
Catalog No. ABIN7536614
Casilio HDR EpEd Mammalian Expression Vector pmax-BRCA1_53BP1 Kanamycin CMV Promoter unconjugated Transient
Type:
Casilio HDR
Application:
Epigenetic Editing
Gene:
BRCA1_53BP1
Species:
Various Species
Vector type:
Mammalian Expression Vector
Vector backbone:
pmax-BRCA1_53BP1
Resistance Gene:
Kanamycin
Promoter:
CMV Promoter
Expression:
Transient
Catalog No. ABIN7536615
Casilio HDR EpEd Mammalian Expression Vector pmax-FANCF_53BP1 Kanamycin CMV Promoter unconjugated Transient
Type:
Casilio HDR
Application:
Epigenetic Editing
Gene:
FANCF_53BP1
Species:
Various Species
Vector type:
Mammalian Expression Vector
Vector backbone:
pmax-FANCF_53BP1
Resistance Gene:
Kanamycin
Promoter:
CMV Promoter
Expression:
Transient
Catalog No. ABIN7536616
Casilio HDR EpEd Mammalian Expression Vector pCR8-sgFE-CXCR4-5xPBSa Spectinomycin U6 Promoter unconjugated Transient
Type:
Casilio HDR
Application:
Epigenetic Editing
Gene:
SgFE-CXCR4-5xPBSa
Species:
Various Species
Vector type:
Mammalian Expression Vector
Vector backbone:
pCR8-sgFE-CXCR4-5xPBSa
Resistance Gene:
Spectinomycin
Promoter:
U6 Promoter
Expression:
Transient
Catalog No. ABIN7536619
  • Type
    • Plasmid
  • Supplier
    • antibodies-online
  • Target
    • BRCA1_53BP1
    • BRCA1_PUFa
    • CRISPR-Cas9
    • CtIP(T847E)_53BP1
    • CtIP(T847E)_PUFa
    • FANCF_53BP1
    • FANCF_PUFa
    • SgFE-CXCR4-5xPBSa
    • SgFE-EMX1-5xPBSa
    • XRCC3_53BP1
    • XRCC3_PUFa
  • Reactivity
    • Various Species
  • Application
    • Epigenetic Editing (EpEd)
  • Conjugate
    • Un-conjugated
  • Vector Backbone
    • pCR8-sgFE-CXCR4-5xPBSa
    • pCR8-sgFE-EMX1-5xPBSa
    • pmax-BRCA1_53BP1
    • pmax-BRCA1_PUFa
    • pmax-Cas9
    • pmax-CtIP(T847E)_53BP1
    • pmax-CtIP(T847E)_PUFa
    • pmax-FANCF_53BP1
    • pmax-FANCF_PUFa
    • pmax-XRCC3_53BP1
    • pmax-XRCC3_PUFa
  • Vector
    • Mammalian Expression Vector
  • Insert Casilio HDR
    • Casilio HDR
    • cDNA
    • ORF
    • shRNA
    • gRNA + Cas9
    • gRNA
    • Empty
    • Casilio Regulation
    • Casilio Imaging
  • Bacterial Resistance
    • Kanamycin
    • Spectinomycin
  • Expression Type
    • Transient
  • Promoter
    • CMV Promoter
    • U6 Promoter
  • Format
    • Liquid
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