Short Description: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]. More information related to gene alpha Actinin 4.
Synonyms and alternative names related to alpha Actinin 4
actinin alpha 4 (actn4)
actinin alpha 4 (ACTN4)
actinin alpha 4 (Actn4)
actinin, alpha 4 (actn4)
actinin alpha 4 S homeolog (actn4.S)
actinin, alpha 4 (ACTN4)
ACTININ-4
C77391
fsgs
FSGS
fsgs1
FSGS1
wu:fb53f05
zgc:63508
Gene-IDs for different species
Protein level used designations for alpha Actinin 4
actinin, alpha 4
alpha-actinin-4-like
F-actin cross-linking protein
alpha-actinin-4
non-muscle alpha-actinin 4
alpha actinin 4
actinin alpha4 isoform
focal segmental glomerulosclerosis 1
alpha-actinin
Proteomics products related to alpha Actinin 4 Gene
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