BRCA1 (Breast Cancer 1, BRCA1)
Short Description: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009].
More information related to gene BRCA1.
More information related to gene BRCA1.
Products related to BRCA1 Gene:
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87 results
cDNA
Clon
Bacterial Expression Vector
pPB-N-His
Kanamycin
T7 Promoter
His tag
Transient
- Type:
- cDNA
- Application:
- Cloning
- Gene:
- Breast Cancer 1 (BRCA1)
- NCBI Accession:
- NM_012514
- Species:
- Rat
- Vector type:
- Bacterial Expression Vector
- Vector backbone:
- pPB-N-His
- Resistance Gene:
- Kanamycin
- Promoter:
- T7 Promoter
- Fusion Tag:
- His tag
- Expression:
- Transient
Catalog No. ABIN4676193
$6,160.29
Plus shipping costs $50.00
500 ng
Shipping to:
United States
Delivery in 21 to 32 Business Days
cDNA
PExp
Mammalian Expression Vector
pPM-C-His
Kanamycin
CMV Promoter
His tag
Stable
- Type:
- cDNA
- Application:
- Protein Expression
- Gene:
- Breast Cancer 1 (BRCA1)
- NCBI Accession:
- NM_012514
- Species:
- Rat
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pPM-C-His
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- His tag
- Expression:
- Stable, Transient
Catalog No. ABIN4372872
$6,160.29
Plus shipping costs $50.00
500 ng
Shipping to:
United States
Delivery in 21 to 32 Business Days
ORF
Clon
Gateway Cloning Vector
pDONR223
Spectinomycin
unconjugated
Catalog No. ABIN5322373
$235.38
Plus shipping costs $50.00
2 μg
Shipping to:
United States
Delivery in 15 to 19 Business Days
ORF
Clon
Gateway Cloning Vector
pDONR223
Spectinomycin
unconjugated
Catalog No. ABIN5325823
$270.13
Plus shipping costs $50.00
2 μg
Shipping to:
United States
Delivery in 15 to 19 Business Days
ORF
PExp
Mammalian Expression Vector
pcDNA3.1+C-(K)-DYK
Ampicillin
CMV Promoter
DYKDDDDK Tag
Transient
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Breast Cancer 1 (BRCA1)
- NCBI Accession:
- NM_007300
- Gene ID:
- 672 (Human, BRCA1)
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pcDNA3.1+C-(K)-DYK
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- DYKDDDDK Tag
- Expression:
- Transient, Stable
Catalog No. ABIN4947164
$379.00
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 26 to 27 Business Days
OriGene sr300469
RNAi
BRCA1
Species: Human
HPLC purified
- Application:
- RNA Interference
- Gene:
- Breast Cancer 1
- Species:
- Human
- Purification:
- HPLC purified
Catalog No. ABIN3340263
$435.60
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 4 to 9 Business Days
ORF
PExp
Mammalian Expression Vector
pcDNA3.1+C-(K)-DYK
Ampicillin
CMV Promoter
DYKDDDDK Tag
Transient
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Breast Cancer 1 (BRCA1)
- NCBI Accession:
- NM_007298
- Gene ID:
- 672 (Human, BRCA1)
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pcDNA3.1+C-(K)-DYK
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- DYKDDDDK Tag
- Expression:
- Transient, Stable
Catalog No. ABIN4944472
$559.00
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 31 to 32 Business Days
OriGene sr512467
RNAi
BRCA1
Species: Rat
HPLC purified
- Application:
- RNA Interference
- Gene:
- Breast Cancer 1
- Species:
- Rat
- Purification:
- HPLC purified
Catalog No. ABIN3361236
$512.82
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
OriGene sr423219
RNAi
BRCA1
Species: Mouse
HPLC purified
- Application:
- RNA Interference
- Gene:
- Breast Cancer 1
- Species:
- Mouse
- Purification:
- HPLC purified
Catalog No. ABIN3350065
$512.82
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
ORF
PExp
Mammalian Expression Vector
pcDNA3.1+C-(K)-DYK
Ampicillin
CMV Promoter
DYKDDDDK Tag
Transient
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Breast Cancer 1 (BRCA1)
- NCBI Accession:
- NM_007299
- Gene ID:
- 672 (Human, BRCA1)
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pcDNA3.1+C-(K)-DYK
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- DYKDDDDK Tag
- Expression:
- Transient, Stable
Catalog No. ABIN4944473
$709.00
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 31 to 32 Business Days
Synonyms and alternative names related to BRCA1
- BRCA1, DNA repair associated (BRCA1)
- breast cancer 1 (brca1)
- breast cancer 1, early onset (LOC755086)
- breast cancer 1, early onset (Brca1)
- BRCA1, DNA repair associated (Brca1)
- breast cancer 1, early onset (BRCA1)
- breast cancer 1 L homeolog (brca1.L)
- brca1
- BRCA1
- BRCAI
- brcai
- BRCC1
- brcc1
- BROVCA1
- IRIS
- iris
- LOC100224649
- PNCA4
- PPP1R53
- PSCP
- pscp
- RNF53
- rnf53
Gene-IDs for different species
Protein level used designations for BRCA1
- BRCA1/BRCA2-containing complex, subunit 1
- RING finger protein 53
- breast and ovarian cancer susceptibility protein 1
- breast and ovarian cancer sususceptibility protein 1
- breast cancer type 1 susceptibility protein
- protein phosphatase 1, regulatory subunit 53
- BRCA1 homologue
- breast cancer type 1 susceptibility protein homolog
- breast cancer 1, early onset
- BRCA1 homolog
- breast and ovarian cancer susceptibility protein
- breast cancer associated 1
Proteomics products related to BRCA1 Gene
Other products related to BRCA1 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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