CDK5R1 (Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35), CDK5R1)
Short Description: The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5)\; the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008].
More information related to gene CDK5R1.
More information related to gene CDK5R1.
Products related to CDK5R1 Gene:
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OriGene sr305844
RNAi
CDK5R1
Species: Human
HPLC purified
- Application:
- RNA Interference
- Gene:
- Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35)
- Species:
- Human
- Purification:
- HPLC purified
Catalog No. ABIN3345606
$512.82
Plus shipping costs $50.00
1 kit
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Synonyms and alternative names related to CDK5R1
- cyclin dependent kinase 5 regulatory subunit 1 (CDK5R1)
- cyclin-dependent kinase 5, regulatory subunit 1b (p35) (cdk5r1b)
- cyclin-dependent kinase 5 regulatory subunit 1 (Cdk5r1)
- S100 calcium binding protein A9 (S100A9)
- cyclin-dependent kinase 5, regulatory subunit 1 (p35) (Cdk5r1)
- cyclin-dependent kinase 5, regulatory subunit 1 (p35) L homeolog (cdk5r1.L)
- cyclin dependent kinase 5 regulatory subunit 1 (Cdk5r1)
- CDK5P35
- CDK5R
- Cdk5r
- cdk5r1
- CDK5R1
- D11Bwg0379e
- NCK5A
- p23
- p25
- P25/P35
- p35
- p35nck5a
- Xp35.1
- zgc:92814
Gene-IDs for different species
Protein level used designations for CDK5R1
- CDK5 activator 1
- TPKII regulatory subunit
- cyclin-dependent kinase 5 activator 1
- cyclin-dependent kinase 5 regulatory subunit 1
- neuronal CDK5 activator
- regulatory partner for CDK5 kinase
- tau protein kinase II 23kDa subunit
- cyclin-dependent kinase 5 regulatory subunit
- cyclin-dependent kinase 5, regulatory subunit 1 (p35)
- p23
- tau protein kinase II 23 kDa subunit
- BEE22
- S100 calcium-binding protein A9
- calgranulin-B
- neutrophil cytosolic 23 kDa protein
- protein S100-A9
- cyclin-dependent kinase 5, regulatory subunit (p35) 1
Proteomics products related to CDK5R1 Gene
Other products related to CDK5R1 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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