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CDT2/RAMP (Denticleless E3 Ubiquitin Protein Ligase Homolog, DTL)

Short Description: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity).
More information related to gene CDT2/RAMP.

Products related to CDT2/RAMP Gene:

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55 results

Mouse DTL shRNA in Retroviral Vector
OriGene tr509326 shRNA RNAi Retroviral Vector pRS Ampicillin U6 Promoter unconjugated Transient
Type:
shRNA
Application:
RNA Interference
Gene:
Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
Species:
Mouse
Vector type:
Retroviral Vector
Vector backbone:
pRS
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter
Expression:
Transient, Stable
Catalog No. ABIN3541650
$874.17
Plus shipping costs $50.00
1 kit
Shipping to: United States
Delivery in 16 to 17 Business Days
Details
Details
Human DTL cDNA Clone in Mammalian Expression Vector (Myc-DYKDDDDK Tag)
OriGene sc337207 cDNA PExp Mammalian Expression Vector pCMV6-Entry Kanamycin Enhanced CMV Promoter unconjugated Transient
Type:
cDNA
Application:
Protein Expression
Gene:
Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL)
NCBI Accession:
NM_001286230,NP_001273159
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pCMV6-Entry
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
Enhanced CMV Promoter
Expression:
Transient
Catalog No. ABIN3290890
$687.06
Plus shipping costs $50.00
10 μg
Shipping to: United States
Delivery in 21 to 22 Business Days
Details
Details
Mouse DTL cDNA Clone in Mammalian Expression Vector (Myc-DYKDDDDK Tag)
OriGene mc221182 cDNA PExp Mammalian Expression Vector pCMV6-Entry Kanamycin Enhanced CMV Promoter unconjugated Transient
Type:
cDNA
Application:
Protein Expression
Gene:
Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
NCBI Accession:
NM_029766,NP_084042
Species:
Mouse
Vector type:
Mammalian Expression Vector
Vector backbone:
pCMV6-Entry
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
Enhanced CMV Promoter
Expression:
Transient
Catalog No. ABIN3290888
$727.65
Plus shipping costs $50.00
10 μg
Shipping to: United States
Delivery in 31 to 32 Business Days
Details
Details
Human DTL cDNA Clone in Mammalian Expression Vector (Myc-DYKDDDDK Tag)
OriGene sc336242 cDNA PExp Mammalian Expression Vector pCMV6-Entry Kanamycin Enhanced CMV Promoter unconjugated Transient
Type:
cDNA
Application:
Protein Expression
Gene:
Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL)
NCBI Accession:
NM_001286229,NP_001273158
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pCMV6-Entry
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
Enhanced CMV Promoter
Expression:
Transient
Catalog No. ABIN3290889
$497.97
Plus shipping costs $50.00
10 μg
Shipping to: United States
Delivery in 16 to 17 Business Days
Details
Details
Human DTL cDNA Clone in Mammalian Expression Vector
OriGene sc114271 cDNA PExp Mammalian Expression Vector pCMV6-XL5 Ampicillin Enhanced CMV Promoter unconjugated Transient
Type:
cDNA
Application:
Protein Expression
Gene:
Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
NCBI Accession:
NM_016448,NP_057532
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pCMV6-XL5
Resistance Gene:
Ampicillin
Promoter:
Enhanced CMV Promoter, T7 Promoter
Expression:
Transient
Catalog No. ABIN3383729
$662.31
Plus shipping costs $50.00
10 μg
Shipping to: United States
Delivery in 4 to 9 Business Days
Details
Details
Human DTL ORF Clone in Mammalian Expression Vector (Myc-DYKDDDDK Tag)
OriGene rc238348 ORF PExp Mammalian Expression Vector pCMV6-Entry Kanamycin CMV Promoter Myc-DYKDDDDK Tag Transient
Type:
ORF
Application:
Protein Expression
Gene:
Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pCMV6-Entry
Resistance Gene:
Kanamycin
Promoter:
CMV Promoter
Fusion Tag:
Myc-DYKDDDDK Tag
Expression:
Transient
Catalog No. ABIN5477063
$497.97
Plus shipping costs $50.00
10 μg
Shipping to: United States
Delivery in 16 to 17 Business Days
Details
Details
Human DTL ORF Clone in Mammalian Expression Vector (Myc-DYKDDDDK Tag)
OriGene rc239313 ORF PExp Mammalian Expression Vector pCMV6-Entry Kanamycin CMV Promoter Myc-DYKDDDDK Tag Transient
Type:
ORF
Application:
Protein Expression
Gene:
Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pCMV6-Entry
Resistance Gene:
Kanamycin
Promoter:
CMV Promoter
Fusion Tag:
Myc-DYKDDDDK Tag
Expression:
Transient
Catalog No. ABIN5477064
$686.07
Plus shipping costs $50.00
10 μg
Shipping to: United States
Delivery in 21 to 22 Business Days
Details
Details
Human DTL ORF Clone in Mammalian Expression Vector (DYKDDDDK Tag)
ORF PExp Mammalian Expression Vector pcDNA3.1+C-(K)-DYK Ampicillin CMV Promoter DYKDDDDK Tag Transient
ISO 9001:2008
Type:
ORF
Application:
Protein Expression
Gene:
Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL)
NCBI Accession:
NM_001286230
Gene ID:
51514 (Human, DTL)
Vector type:
Mammalian Expression Vector
Vector backbone:
pcDNA3.1+C-(K)-DYK
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
DYKDDDDK Tag
Expression:
Transient, Stable
Catalog No. ABIN4944038
$559.00
Plus shipping costs $50.00
10 μg
Shipping to: United States
Delivery in 31 to 32 Business Days
Details
Details
Human DTL ORF Clone in Mammalian Expression Vector (DYKDDDDK Tag)
ORF PExp Mammalian Expression Vector pcDNA3.1+C-(K)-DYK Ampicillin CMV Promoter DYKDDDDK Tag Transient
ISO 9001:2008
Type:
ORF
Application:
Protein Expression
Gene:
Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL)
NCBI Accession:
NM_016448
Gene ID:
51514 (Human, DTL)
Vector type:
Mammalian Expression Vector
Vector backbone:
pcDNA3.1+C-(K)-DYK
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
DYKDDDDK Tag
Expression:
Transient, Stable
Catalog No. ABIN4939929
$559.00
Plus shipping costs $50.00
10 μg
Shipping to: United States
Delivery in 4 to 7 Business Days
Details
Details
Human DTL ORF Clone in Mammalian Expression Vector (DYKDDDDK Tag)
ORF PExp Mammalian Expression Vector pcDNA3.1+C-(K)-DYK Ampicillin CMV Promoter DYKDDDDK Tag Transient
ISO 9001:2008
Type:
ORF
Application:
Protein Expression
Gene:
Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL)
NCBI Accession:
NM_001286229
Gene ID:
51514 (Human, DTL)
Vector type:
Mammalian Expression Vector
Vector backbone:
pcDNA3.1+C-(K)-DYK
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
DYKDDDDK Tag
Expression:
Transient, Stable
Catalog No. ABIN4939928
$319.00
Plus shipping costs $50.00
10 μg
Shipping to: United States
Delivery in 4 to 7 Business Days
Details
Details
  • Type
    • Plasmid
    • Primer
  • Supplier
    • antibodies-online
    • OriGene
    • GenScript
    • ProteoGenix
  • Reactivity
    • Human
    • Mouse
  • Application
    • Protein Expression (PExp)
    • Cloning (Clon)
    • RNA Interference (RNAi)
    • Genome Editing with Engineered Nucleases (GEEN)
  • Conjugate
    • Un-conjugated
    • GFP tag
    • Myc-DYKDDDDK Tag
    • His tag
    • DYKDDDDK Tag
    • HA tag
    • His-GST
    • His-MBP
    • RFP tag
  • Vector Backbone
    • pCMV6-Entry
    • pLenti-U6-sgRNA-PGK-Neo
    • pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
    • pORF
    • pPB-His-GST
    • pPB-His-MBP
    • pPB-N-His
    • pPM-C-HA
    • pPM-C-His
    • pcDNA3.1+C-(K)-DYK
    • pCas-Guide
    • pDONR223
    • pGFP-C-shLenti
    • pGFP-V-RS
    • pLenti-C-Myc-DDK
    • pLenti-C-mGFP
    • pRFP-C-RS
    • pRS
    • pCMV6-AC-GFP
    • pCMV6-XL5
  • Vector
    • Mammalian Expression Vector
    • Lentiviral Vector
    • Bacterial Expression Vector
    • Retroviral Vector
    • Cloning Vector
    • Gateway Cloning Vector
  • Insert
    • cDNA
    • ORF
    • shRNA
    • gRNA + Cas9
    • gRNA
  • Type of Oligonucleotide
    • siRNA Oligo
  • Bacterial Resistance
    • Kanamycin
    • Ampicillin
    • Chloramphenicol
    • Spectinomycin
  • Expression Type
    • Transient
    • Stable
  • Selectable Marker
    • Neomycin
    • Puromycin
  • Promoter
    • U6 Promoter
    • CMV Promoter
    • T7 Promoter
    • Enhanced CMV Promoter
    • PGK Promoter
    • SFFV Promoter
  • Format
    • Lyophilized
    • Liquid
    • Viral Particles

Synonyms and alternative names related to CDT2/RAMP

  • denticleless E3 ubiquitin protein ligase homolog (DTL)
  • denticleless E3 ubiquitin protein ligase (Dtl)
  • denticleless E3 ubiquitin protein ligase homolog (Dtl)
  • denticleless E3 ubiquitin protein ligase homolog S homeolog (dtl.S)
  • denticleless E3 ubiquitin protein ligase homolog (Drosophila) (dtl)
  • 2810047L02Rik
  • 5730564G15Rik
  • cb151
  • CDT2
  • cdt2
  • cdt2-a
  • chunp6871
  • DCAF2
  • dcaf2
  • L2DTL
  • l2dtl
  • RAMP
  • Ramp
  • ramp
  • RGD1310439
  • wu:fb54b02

Gene-IDs for different species

Protein level used designations for CDT2/RAMP

  • DDB1 and CUL4 associated factor 2
  • DDB1- and CUL4-associated factor 2
  • RA regulated nuclear matrix associated protein
  • RA-regulated nuclear matrix-associated protein
  • denticleless homolog
  • denticleless protein homolog
  • lethal(2) denticleless protein homolog
  • retinoic acid-regulated nuclear matrix-associated protein
  • Meth A ramp
  • meth A retinoic acid-regulated nuclear matrix-associated protein
  • retinoic-acid regulated nuclear matrix-associated protein
  • denticleless protein homolog A
Other products related to CDT2/RAMP such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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