CDT2/RAMP (Denticleless E3 Ubiquitin Protein Ligase Homolog, DTL)
Short Description: Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity).
More information related to gene CDT2/RAMP.
More information related to gene CDT2/RAMP.
Products related to CDT2/RAMP Gene:
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55 results
OriGene rg207280
ORF
PExp
Mammalian Expression Vector
pCMV6-AC-GFP
Ampicillin
CMV Promoter
GFP tag
Stable
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-AC-GFP
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- GFP tag
- Expression:
- Stable, Transient
Catalog No. ABIN5436938
$781.11
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 8 to 11 Business Days
OriGene rc207280l1
ORF
PExp
Lentiviral Vector
pLenti-C-Myc-DDK
Chloramphenicol
CMV Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
- NCBI Accession:
- NM_016448,NP_057532
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-C-Myc-DDK
- Resistance Gene:
- Chloramphenicol
- Promoter:
- CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN5436941
$958.32
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 8 to 11 Business Days
OriGene rc207280
ORF
PExp
Mammalian Expression Vector
pCMV6-Entry
Kanamycin
CMV Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
- NCBI Accession:
- NM_016448,NP_057532
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-Entry
- Resistance Gene:
- Kanamycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN5436939
$661.32
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 8 to 11 Business Days
OriGene rc207280l2
ORF
PExp
Lentiviral Vector
pLenti-C-mGFP
Chloramphenicol
CMV Promoter
GFP tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
- NCBI Accession:
- NM_016448,NP_057532
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-C-mGFP
- Resistance Gene:
- Chloramphenicol
- Promoter:
- CMV Promoter
- Fusion Tag:
- GFP tag
- Expression:
- Transient
Catalog No. ABIN5436940
$958.32
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 21 to 22 Business Days
OriGene sr309819
RNAi
DTL
Species: Human
HPLC purified
- Application:
- RNA Interference
- Gene:
- Denticleless E3 Ubiquitin Protein Ligase Homolog
- Species:
- Human
- Purification:
- HPLC purified
Catalog No. ABIN3285855
$512.82
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
Synonyms and alternative names related to CDT2/RAMP
- denticleless E3 ubiquitin protein ligase homolog (DTL)
- denticleless E3 ubiquitin protein ligase (Dtl)
- denticleless E3 ubiquitin protein ligase homolog (Dtl)
- denticleless E3 ubiquitin protein ligase homolog S homeolog (dtl.S)
- denticleless E3 ubiquitin protein ligase homolog (Drosophila) (dtl)
- 2810047L02Rik
- 5730564G15Rik
- cb151
- CDT2
- cdt2
- cdt2-a
- chunp6871
- DCAF2
- dcaf2
- L2DTL
- l2dtl
- RAMP
- Ramp
- ramp
- RGD1310439
- wu:fb54b02
Gene-IDs for different species
Protein level used designations for CDT2/RAMP
- DDB1 and CUL4 associated factor 2
- DDB1- and CUL4-associated factor 2
- RA regulated nuclear matrix associated protein
- RA-regulated nuclear matrix-associated protein
- denticleless homolog
- denticleless protein homolog
- lethal(2) denticleless protein homolog
- retinoic acid-regulated nuclear matrix-associated protein
- Meth A ramp
- meth A retinoic acid-regulated nuclear matrix-associated protein
- retinoic-acid regulated nuclear matrix-associated protein
- denticleless protein homolog A
Proteomics products related to CDT2/RAMP Gene
Other products related to CDT2/RAMP such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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