Cullin 1 (Cullin 1, CUL1)
Short Description: Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'\; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110 (By similarity).
More information related to gene Cullin 1.
More information related to gene Cullin 1.
Products related to Cullin 1 Gene:
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65 results
OriGene rc224650
ORF
PExp
Mammalian Expression Vector
pCMV6-Entry
Kanamycin
CMV Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Cullin 1 (CUL1)
- NCBI Accession:
- NM_003592,NP_003583
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-Entry
- Resistance Gene:
- Kanamycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN5379003
$703.89
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 8 to 11 Business Days
OriGene rr215379
ORF
PExp
Mammalian Expression Vector
pCMV6-Entry
Kanamycin
CMV Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Cullin 1 (CUL1)
- NCBI Accession:
- NM_001108627,NP_001102097
- Species:
- Rat
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-Entry
- Resistance Gene:
- Kanamycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN5379004
$774.18
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 31 to 32 Business Days
OriGene sr305540
RNAi
CUL1
Species: Human
HPLC purified
1
- Application:
- RNA Interference
- Gene:
- Cullin 1
- Species:
- Human
- Purification:
- HPLC purified
Catalog No. ABIN3345307
$512.82
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 4 to 9 Business Days
ORF
Clon
Gateway Cloning Vector
pDONR223
Spectinomycin
unconjugated
Catalog No. ABIN5317324
$215.19
Plus shipping costs $50.00
2 μg
Shipping to:
United States
Delivery in 15 to 19 Business Days
ORF
Clon
Gateway Cloning Vector
pDONR223
Spectinomycin
unconjugated
Catalog No. ABIN5325549
$226.33
Plus shipping costs $50.00
2 μg
Shipping to:
United States
Delivery in 15 to 19 Business Days
Synonyms and alternative names related to Cullin 1
- cullin 1 (CUL1)
- cullin-1 (LOC100282292)
- cullin 1 (cul1)
- cullin-1 (ATEG_00491)
- cullin-1 (EDI_072700)
- cullin-1 (EDI_264400)
- Cullin 1 (SJAG_02591)
- Cullin-1 (BDBG_03785)
- cullin 1 (Cul1)
- cullin 1a (cul1a)
- cullin 1 S homeolog (cul1.S)
- Cullin-1 (cul-1)
- cullin 1b (cul1b)
- ATCUL1
- AUXIN RESISTANT 6
- AXR6
- Cul-1
- Cul1
- cul1
- Cullin-1
- cullin-1
- cullin 1
- LOC100282292
- T10P11.26
- T10P11_26
- wu:fc13a10
- wu:fi43h07
- wu:fj43a08
- zgc:55483
- zgc:55747
- zgc:77500
- zgc:111899
Gene-IDs for different species
Protein level used designations for Cullin 1
- CUL-1
- cullin-1
- Cullin-1
- Cell division control 53 homolog
Proteomics products related to Cullin 1 Gene
Other products related to Cullin 1 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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