Short Description: This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008]. More information related to gene Dynactin 1.
Synonyms and alternative names related to Dynactin 1
dynactin subunit 1 (DCTN1)
dynactin subunit 1 (Dctn1)
dynactin 1 (Dctn1)
Dynactin 1, p150 subunit (DCTN1-p150)
dynactin subunit 1 L homeolog (dctn1.L)
AL022633
CG9206
Chip150
DAP-150
DCTN1
DKFZp469C1813
Dmel\\CG9206
DP-150
Dynactin-1
DYNA_DROME
FCP-D
Glu
Glued
glued
P135
p150
P150
p150/Glued
p150/glued
p150
P150[Glued]
p150[Glued]
p150[glued]
t1
Gene-IDs for different species
Protein level used designations for Dynactin 1
150 kDa dynein-associated polypeptide
dynactin 1 (p150, glued homolog, Drosophila)
dynactin subunit 1
DAP-150
DP-150
p150-glued
dynactin 1
dynactin subunit 1-like
dynactin 1, retrograde axonal transport
CG9206-PA
Gl-PA
dynactin
dynactin P150
glued
p150[glued]
p150glued
dynactin 1 (p150, glued homolog)
Proteomics products related to Dynactin 1 Gene
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