EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3, EGLN3)
Short Description: Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. ELGN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM2 in hypoxia, limiting glycolysis. Under normoxia, hydroxylates and regulates the stability of ADRB2. Regulator of cardiomyocyte and neuronal apoptosis. In cardiomyocytes, inhibits the anti-apoptotic effect of BCL2 by disrupting the BAX-BCL2 complex. In neurones, has a NGF-induced proapoptotic effect, probably through regulating CASP3 activity. Also essential for hypoxic regulation of neutrophilic inflammation.
More information related to gene EGLN3.
More information related to gene EGLN3.
Products related to EGLN3 Gene:
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57 results
OriGene rr211606
ORF
PExp
Mammalian Expression Vector
pCMV6-Entry
Kanamycin
CMV Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Egl Nine Homolog 3 (C. Elegans) (EGLN3)
- NCBI Accession:
- NM_019371,NP_062244
- Species:
- Rat
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-Entry
- Resistance Gene:
- Kanamycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN5401150
$497.97
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 21 to 22 Business Days
OriGene rc210319l2
ORF
PExp
Lentiviral Vector
pLenti-C-mGFP
Chloramphenicol
CMV Promoter
GFP tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Egl Nine Homolog 3 (C. Elegans) (EGLN3)
- NCBI Accession:
- NM_022073,NP_071356
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-C-mGFP
- Resistance Gene:
- Chloramphenicol
- Promoter:
- CMV Promoter
- Fusion Tag:
- GFP tag
- Expression:
- Transient
Catalog No. ABIN5401151
$594.00
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 21 to 22 Business Days
OriGene rg210319
ORF
PExp
Mammalian Expression Vector
pCMV6-AC-GFP
Ampicillin
CMV Promoter
GFP tag
Stable
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3)
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-AC-GFP
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- GFP tag
- Expression:
- Stable, Transient
Catalog No. ABIN5401148
$484.11
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 8 to 11 Business Days
OriGene rc210319l1
ORF
PExp
Lentiviral Vector
pLenti-C-Myc-DDK
Chloramphenicol
CMV Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Egl Nine Homolog 3 (C. Elegans) (EGLN3)
- NCBI Accession:
- NM_022073,NP_071356
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-C-Myc-DDK
- Resistance Gene:
- Chloramphenicol
- Promoter:
- CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN5401153
$594.00
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 8 to 11 Business Days
OriGene rc210319
ORF
PExp
Mammalian Expression Vector
pCMV6-Entry
Kanamycin
CMV Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Egl Nine Homolog 3 (C. Elegans) (EGLN3)
- NCBI Accession:
- NM_022073,NP_071356
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-Entry
- Resistance Gene:
- Kanamycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN5401149
$297.00
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 8 to 11 Business Days
OriGene sr401799
RNAi
EGLN3
Species: Mouse
HPLC purified
- Application:
- RNA Interference
- Gene:
- Egl-9 Family Hypoxia Inducible Factor 3
- Species:
- Mouse
- Purification:
- HPLC purified
Catalog No. ABIN3275829
$512.82
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
OriGene sr314329
RNAi
EGLN3
Species: Human
HPLC purified
- Application:
- RNA Interference
- Gene:
- Egl-9 Family Hypoxia Inducible Factor 3
- Species:
- Human
- Purification:
- HPLC purified
Catalog No. ABIN3311331
$512.82
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 4 to 9 Business Days
Synonyms and alternative names related to EGLN3
- egl-9 family hypoxia-inducible factor 3 (egln3)
- egl-9 family hypoxia inducible factor 3 (EGLN3)
- egl-9 family hypoxia-inducible factor 3 L homeolog (egln3.L)
- egl-9 family hypoxia-inducible factor 3 (Egln3)
- 2610021G09Rik
- AI505553
- AI648162
- EGLN3
- Hif-p4h-3
- HIFP4H3
- HIFPH3
- PHD-3
- phd3
- PHD3
- Phd3
- SM-20
- wu:fj78a08
- zgc:77019
Gene-IDs for different species
Protein level used designations for EGLN3
- Hif-p4h-3
- egl nine homolog 3
- phd3
- egl nine homolog 3 (C. elegans)
- HIF-PH3
- HIF-prolyl hydroxylase 3
- HPH-3
- egl nine homolog 3, mitochondrial
- factor-responsive smooth muscle protein
- hypoxia-inducible factor prolyl hydroxylase 3
- prolyl hydroxylase domain-containing protein 3
- HIF prolyl hydroxylase 3
- HPH-1
- egl nine-like protein 3 isoform
Proteomics products related to EGLN3 Gene
Other products related to EGLN3 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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