GCAP1 (Guanylate Cyclase Activator 1A (Retina), GUCA1A)
Short Description: This gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein encoded by this gene, guanylyl cyclase activating protein 1 (GCAP1), mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3)\; a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations\; causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia. [provided by RefSeq, Feb 2009].
More information related to gene GCAP1.
More information related to gene GCAP1.
Products related to GCAP1 Gene:
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62 results
ORF
PExp
Mammalian Expression Vector
pcDNA3.1+C-(K)-DYK
Ampicillin
CMV Promoter
DYKDDDDK Tag
Transient
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Guanylate Cyclase Activator 1A (Retina) (GUCA1A)
- NCBI Accession:
- NM_000409
- Gene ID:
- 2978 (Human, GUCA1A)
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pcDNA3.1+C-(K)-DYK
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- DYKDDDDK Tag
- Expression:
- Transient, Stable
Catalog No. ABIN4938937
ORF
Clon
Gateway Cloning Vector
pDONR223
Spectinomycin
unconjugated
Catalog No. ABIN5315561
$204.05
Plus shipping costs $50.00
2 μg
Shipping to:
United States
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Synonyms and alternative names related to GCAP1
- guanylate cyclase activator 1A (GUCA1A)
- guanylate cyclase activator 1A (Guca1a)
- guanylate cyclase activator 1A L homeolog (guca1a.L)
- guanylate cyclase activator 1A (retina) (guca1a)
- guanylate cyclase activator 1a (retina) (Guca1a)
- guanylate cyclase activator 1A (guca1a)
- C6orf131
- COD3
- CORD14
- dJ139D8.6
- GC-A
- GCAP
- GCAP1
- Gcap1
- gcap1
- GUCA
- GUCA1
- Guca1
- GUCA1A
- guca1a
- MGC84170
- MGC146317
- mGCAP1
Gene-IDs for different species
Protein level used designations for GCAP1
- GCAP 1
- cone dystrophy 3
- guanylate cyclase-activating protein, photoreceptor 1
- guanylin 1, retina
- guanylyl cyclase-activating protein 1
- guanylate cyclase activator 1A (retina)
Proteomics products related to GCAP1 Gene
Other products related to GCAP1 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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