Short Description: This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. More information related to gene Haptoglobin.
Synonyms and alternative names related to Haptoglobin
haptoglobin (HP)
haptoglobin (hp)
haptoglobin (Hp)
haptoglobin-like (LOC479668)
haptoglobin (LOC101102413)
BP
HP
HP-1
HP2ALPHA2
HPA1S
HPR
wu:fb64e01
Zonulin
Gene-IDs for different species
Protein level used designations for Haptoglobin
haptoglobin
HpL
binding peptide
haptoglobin alpha(1S)-beta
haptoglobin alpha(2FS)-beta
haptoglobin, alpha polypeptide
haptoglobin, beta polypeptide
zonulin
liver regeneration-related protein LRRG173
haptoglobin-related protein
haptoglobin alpha 1S
Proteomics products related to Haptoglobin Gene
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