IDE (Insulin-Degrading Enzyme, IDE)
Short Description: This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009].
More information related to gene IDE.
More information related to gene IDE.
Products related to IDE Gene:
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OriGene kn420700
gRNA + Cas9
GEEN
Mammalian Expression Vector
pCas-Guide
Ampicillin
U6 Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- gRNA + Cas9
- Application:
- Genome Editing with Engineered Nucleases
- Gene:
- Insulin-Degrading Enzyme (IDE)
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCas-Guide
- Resistance Gene:
- Ampicillin
- Promoter:
- U6 Promoter, Enhanced CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN3238690
$1,640.43
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 21 to 22 Business Days
Synonyms and alternative names related to IDE
- insulin degrading enzyme (IDE)
- insulin-degrading enzyme (ide)
- insulin-degrading enzyme (LOC591315)
- insulin-degrading enzyme (CC1G_01115)
- insulin-degrading enzyme (Bm1_26615)
- insulin-degrading enzyme (PTRG_10875)
- metallopeptidase (SJAG_01430)
- insulin-degrading enzyme (EBI_21700)
- insulin-degrading enzyme (VDBG_06702)
- insulin-degrading enzyme (LOAG_08082)
- insulin-degrading enzyme (PGTG_04982)
- insulin-degrading enzyme (Tsp_00424)
- insulin degrading enzyme (Ide)
- 1300012G03Rik
- 4833415K22Rik
- AA675336
- AI507533
- IDE
- INSDEGM
- INSULYSIN
- zgc:162603
Gene-IDs for different species
Protein level used designations for IDE
- insulysin
- insulin-degrading enzyme
- insulin-degrading enzyme-like
- insulin protease
- insulinase
- Abeta-degrading protease
Proteomics products related to IDE Gene
Other products related to IDE such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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