Short Description: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of H2B histone (By similarity), RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones (By similarity), RPL4 and RPL6. More information related to gene Importin 9.
Synonyms and alternative names related to Importin 9
importin 9 (IPO9)
importin 9 (Ipo9)
importin 9 (ipo9)
importin 9 L homeolog (ipo9.L)
importin 9 (cnrP)
RAN binding protein 9 (Ranbp9)
RAN binding protein 9 L homeolog (ranbp9.L)
RAN binding protein 9 (RANBP9)
RAN binding protein 9 (ranbp9)
0710008K06Rik
AI845704
bpm-l
bpm90
C78347
cb457
DDBDRAFT_0205722
DDBDRAFT_0229883
DDB_0205722
DDB_0229883
Imp9
IPO9
MGC81741
mKIAA1192
Ranbp9
RanBP9
ranbp9
ranbp9-a
ranbp9-b
ranbp9b
RanBPM
RGD1561940
wu:fc23d12
zgc:66429
zgc:158650
Gene-IDs for different species
Protein level used designations for Importin 9
importin-9
ran-binding protein 9
ranBP9
Ran binding protein 9
imp9a
imp9b
importin-9a
importin-9b
importin 9
importin-9-like
LOW QUALITY PROTEIN: ran-binding protein 9
ran-binding protein M
RAN binding protein 9 b
Ran-binding protein M
Proteomics products related to Importin 9 Gene
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