LAMB2 (Laminin, beta 2 (Laminin S), LAMB2)
Short Description: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 2. The beta 2 chain contains the 7 structural domains typical of beta chains of laminin, including the short alpha region. However, unlike beta 1 chain, beta 2 has a more restricted tissue distribution. It is enriched in the basement membrane of muscles at the neuromuscular junctions, kidney glomerulus and vascular smooth muscle. Transgenic mice in which the beta 2 chain gene was inactivated by homologous recombination, showed defects in the maturation of neuromuscular junctions and impairment of glomerular filtration. Alternative splicing involving a non consensus 5' splice site (gc) in the 5' UTR of this gene has been reported. It was suggested that inefficient splicing of this first intron, which does not change the protein sequence, results in a greater abundance of the unspliced form of the transcript than the spliced form. The full-length nature of the spliced transcript is not known. [provided by RefSeq, Aug 2011].
More information related to gene LAMB2.
More information related to gene LAMB2.
Products related to LAMB2 Gene:
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47 results
OriGene mc224935
cDNA
PExp
Mammalian Expression Vector
pCMV6-Entry
Kanamycin
Enhanced CMV Promoter
unconjugated
Transient
1
- Type:
- cDNA
- Application:
- Protein Expression
- Gene:
- Laminin, beta 2 (Laminin S) (LAMB2)
- NCBI Accession:
- NM_008483,NP_032509
- Species:
- Mouse
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-Entry
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Neomycin
- Promoter:
- Enhanced CMV Promoter
- Expression:
- Transient
Catalog No. ABIN3375532
$1,647.36
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 41 to 42 Business Days
ORF
PExp
Mammalian Expression Vector
pcDNA3.1+C-(K)-DYK
Ampicillin
CMV Promoter
DYKDDDDK Tag
Transient
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Laminin, beta 2 (Laminin S) (LAMB2)
- NCBI Accession:
- NM_002292
- Gene ID:
- 3913 (Human, LAMB2)
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pcDNA3.1+C-(K)-DYK
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- DYKDDDDK Tag
- Expression:
- Transient, Stable
Catalog No. ABIN4946873
$1,319.00
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 26 to 27 Business Days
OriGene sc118736
cDNA
PExp
Mammalian Expression Vector
pCMV6-XL6
Ampicillin
Enhanced CMV Promoter
unconjugated
Transient
1
- Type:
- cDNA
- Application:
- Protein Expression
- Gene:
- Laminin, beta 2 (Laminin S) (LAMB2)
- NCBI Accession:
- NM_002292,NP_002283
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-XL6
- Resistance Gene:
- Ampicillin
- Promoter:
- Enhanced CMV Promoter, SP6 Promoter
- Expression:
- Transient
Catalog No. ABIN3393594
$1,496.88
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 4 to 9 Business Days
OriGene rg217480
ORF
PExp
Mammalian Expression Vector
pCMV6-AC-GFP
Ampicillin
CMV Promoter
GFP tag
Stable
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Laminin, beta 2 (Laminin S) (LAMB2)
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-AC-GFP
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- GFP tag
- Expression:
- Stable, Transient
Catalog No. ABIN5443202
$1,693.89
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 21 to 22 Business Days
OriGene rr200947
ORF
PExp
Mammalian Expression Vector
pCMV6-Entry
Kanamycin
CMV Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Laminin, beta 2 (Laminin S) (LAMB2)
- Species:
- Rat
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-Entry
- Resistance Gene:
- Kanamycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN5443204
$1,648.35
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 41 to 42 Business Days
OriGene rc217480
ORF
PExp
Mammalian Expression Vector
pCMV6-Entry
Kanamycin
CMV Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Laminin, beta 2 (Laminin S) (LAMB2)
- NCBI Accession:
- NM_002292,NP_002283
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-Entry
- Resistance Gene:
- Kanamycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN5443203
$1,495.89
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 8 to 11 Business Days
OriGene sr302647
RNAi
LAMB2
Species: Human
HPLC purified
- Application:
- RNA Interference
- Gene:
- Laminin, beta 2 (Laminin S)
- Species:
- Human
- Purification:
- HPLC purified
Catalog No. ABIN3342429
$512.82
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 4 to 9 Business Days
Synonyms and alternative names related to LAMB2
- laminin subunit beta 2 (LAMB2)
- laminin, beta 2 (Lamb2)
- laminin subunit beta 2 (Lamb2)
- laminin subunit beta 2 L homeolog (lamb2.L)
- laminin, beta 2 (laminin S) (LAMB2)
- AW211941
- Lamb-2
- lamb1
- LAMC1
- laminin
- LAMS
- Lams
- lams
- NPHS5
- SLAM
Gene-IDs for different species
Protein level used designations for LAMB2
- S-LAM beta
- S-laminin subunit beta
- laminin B1s chain
- laminin S
- laminin subunit beta-2
- Laminin S
- laminin-11 subunit beta
- laminin-14 subunit beta
- laminin-15 subunit beta
- laminin-3 subunit beta
- laminin-4 subunit beta
- laminin-7 subunit beta
- laminin-9 subunit beta
- laminin chain B3
- laminin chain beta 2
- laminin beta 2
- laminin, beta 1
- gamma 1 (formerly LAMB2)
- laminin, gamma 1 (formerly LAMB2)
Proteomics products related to LAMB2 Gene
Other products related to LAMB2 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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