MAP3K4 (Mitogen-Activated Protein Kinase Kinase Kinase 4, MAP3K4)
Short Description: The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
More information related to gene MAP3K4.
More information related to gene MAP3K4.
Products related to MAP3K4 Gene:
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64 results
OriGene sr423049
RNAi
MAP3K4
Species: Mouse
HPLC purified
- Application:
- RNA Interference
- Gene:
- Mitogen-Activated Protein Kinase Kinase Kinase 4
- Species:
- Mouse
- Purification:
- HPLC purified
Catalog No. ABIN3349899
$512.82
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
OriGene sr508323
RNAi
MAP3K4
Species: Rat
HPLC purified
- Application:
- RNA Interference
- Gene:
- Mitogen-Activated Protein Kinase Kinase Kinase 4
- Species:
- Rat
- Purification:
- HPLC purified
Catalog No. ABIN3357679
$512.82
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
OriGene sr302864
RNAi
MAP3K4
Species: Human
HPLC purified
- Application:
- RNA Interference
- Gene:
- Mitogen-Activated Protein Kinase Kinase Kinase 4
- Species:
- Human
- Purification:
- HPLC purified
Catalog No. ABIN3342646
$512.82
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 4 to 9 Business Days
OriGene tf515154
shRNA
RNAi
Retroviral Vector
pRFP-C-RS
Chloramphenicol
U6 Promoter
RFP tag
Transient
1
- Type:
- shRNA
- Application:
- RNA Interference
- Gene:
- Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4)
- Species:
- Mouse
- Vector type:
- Retroviral Vector
- Vector backbone:
- pRFP-C-RS
- Resistance Gene:
- Chloramphenicol
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter
- Fusion Tag:
- RFP tag
- Expression:
- Transient, Stable
Catalog No. ABIN3677448
$707.85
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
OriGene tg515154
shRNA
RNAi
Retroviral Vector
pGFP-V-RS
Kanamycin
U6 Promoter
GFP tag
Transient
1
- Type:
- shRNA
- Application:
- RNA Interference
- Gene:
- Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4)
- Species:
- Mouse
- Vector type:
- Retroviral Vector
- Vector backbone:
- pGFP-V-RS
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter
- Fusion Tag:
- GFP tag
- Expression:
- Transient, Stable
Catalog No. ABIN3697147
$707.85
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
OriGene tg320416
shRNA
RNAi
Retroviral Vector
pGFP-V-RS
Kanamycin
U6 Promoter
GFP tag
Transient
1
- Type:
- shRNA
- Application:
- RNA Interference
- Gene:
- Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4)
- Species:
- Human
- Vector type:
- Retroviral Vector
- Vector backbone:
- pGFP-V-RS
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter
- Fusion Tag:
- GFP tag
- Expression:
- Transient, Stable
Catalog No. ABIN3744207
$707.85
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
OriGene tf706014
shRNA
RNAi
Retroviral Vector
pRFP-C-RS
Chloramphenicol
U6 Promoter
RFP tag
Transient
1
- Type:
- shRNA
- Application:
- RNA Interference
- Gene:
- Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4)
- Species:
- Rat
- Vector type:
- Retroviral Vector
- Vector backbone:
- pRFP-C-RS
- Resistance Gene:
- Chloramphenicol
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter
- Fusion Tag:
- RFP tag
- Expression:
- Transient, Stable
Catalog No. ABIN3486304
$707.85
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
OriGene tg706014
shRNA
RNAi
Retroviral Vector
pGFP-V-RS
Kanamycin
U6 Promoter
GFP tag
Transient
1
- Type:
- shRNA
- Application:
- RNA Interference
- Gene:
- Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4)
- Species:
- Rat
- Vector type:
- Retroviral Vector
- Vector backbone:
- pGFP-V-RS
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter
- Fusion Tag:
- GFP tag
- Expression:
- Transient, Stable
Catalog No. ABIN3500235
$707.85
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
OriGene tf320416
shRNA
RNAi
Retroviral Vector
pRFP-C-RS
Chloramphenicol
U6 Promoter
RFP tag
Transient
1
- Type:
- shRNA
- Application:
- RNA Interference
- Gene:
- Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4)
- Species:
- Human
- Vector type:
- Retroviral Vector
- Vector backbone:
- pRFP-C-RS
- Resistance Gene:
- Chloramphenicol
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter
- Fusion Tag:
- RFP tag
- Expression:
- Transient, Stable
Catalog No. ABIN3723869
$874.17
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 4 to 9 Business Days
OriGene tr320416
shRNA
RNAi
Retroviral Vector
pRS
Ampicillin
U6 Promoter
unconjugated
Transient
1
- Type:
- shRNA
- Application:
- RNA Interference
- Gene:
- Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4)
- Species:
- Human
- Vector type:
- Retroviral Vector
- Vector backbone:
- pRS
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter
- Expression:
- Transient, Stable
Catalog No. ABIN3661304
$874.17
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
Synonyms and alternative names related to MAP3K4
- mitogen activated protein kinase kinase kinase 4 (Map3k4)
- mitogen-activated protein kinase kinase kinase 4 (MAP3K4)
- mitogen-activated protein kinase kinase kinase 4 (Map3k4)
- D17Rp17
- D17Rp17e
- MAPKKK4
- Mek4b
- MEKK4
- MEKK 4
- Mekk4
- mKIAA0213
- MTK1
- PRO0412
- RP17
- Rp17a
- Tas
Gene-IDs for different species
Protein level used designations for MAP3K4
- mitogen-activated protein kinase kinase kinase 4
- MAP three kinase 1
- MAP/ERK kinase kinase 4
- MAPK/ERK kinase kinase 4
- MEK kinase 4
- MEKK 4
- SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of
- dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4)
- predicted protein of HQ0412
- T-associated sex reversal
- mitogen activated protein kinase kinase kinase 4
Proteomics products related to MAP3K4 Gene
Other products related to MAP3K4 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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