MED12 (Mediator Complex Subunit 12, MED12)
Short Description: The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009].
More information related to gene MED12.
More information related to gene MED12.
Products related to MED12 Gene:
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OriGene rc217206l1
ORF
PExp
Lentiviral Vector
pLenti-C-Myc-DDK
Chloramphenicol
CMV Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Mediator Complex Subunit 12 (MED12)
- NCBI Accession:
- NM_005120,NP_005111
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-C-Myc-DDK
- Resistance Gene:
- Chloramphenicol
- Promoter:
- CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN5386898
$2,965.05
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10 μg
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Synonyms and alternative names related to MED12
- mediator complex subunit 12 (MED12)
- mediator complex subunit 12 (Med12)
- mediator complex subunit 12 (med12)
- 230kDa
- ARC240
- CAGH45
- FGS1
- HOPA
- MED12S
- Mopa
- OHDOX
- OKS
- OPA-1
- OPA1
- TNRC11
- Tnrc11
- TRAP230
- Trap230
Gene-IDs for different species
Protein level used designations for MED12
- CAG repeat protein 45
- OPA-containing protein
- activator-recruited cofactor 240 kDa component
- human opposite paired
- mediator of RNA polymerase II transcription subunit 12
- mediator of RNA polymerase II transcription, subunit 12 homolog
- putative mediator subunit 12
- thyroid hormone receptor-associated protein complex 230 kDa component
- thyroid hormone receptor-associated protein, 230 kDa subunit
- trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit)
- trinucleotide repeat-containing gene 11 protein
- trinucleotide repeat containing 11
- OPA-containing protein 1
- mediator complex subunit 12
- trinucleotide repeat containing 11 (THR-associated protein)
- kohtalo
- kto
- mot_m807
- motionless
- protein kohtalo
- protein motionless
- shiri
- shr
- thyroid hormone receptor-associated protein 230
- thyroid hormone receptor-associated protein complex component TRAP230
- trap230
Proteomics products related to MED12 Gene
Other products related to MED12 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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