MPL (Myeloproliferative Leukemia Virus Oncogene, MPL)
Short Description: In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008].
More information related to gene MPL.
More information related to gene MPL.
Products related to MPL Gene:
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OriGene rc224901
ORF
PExp
Mammalian Expression Vector
pCMV6-Entry
Kanamycin
CMV Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Myeloproliferative Leukemia Virus Oncogene (MPL)
- NCBI Accession:
- NM_005373,NP_005364
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-Entry
- Resistance Gene:
- Kanamycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN5355698
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10 μg
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Synonyms and alternative names related to MPL
- MPL proto-oncogene, thrombopoietin receptor (MPL)
- myeloproliferative leukemia virus oncogene (Mpl)
- MPL proto-oncogene, thrombopoietin receptor (Mpl)
- MPL proto-oncogene, thrombopoietin receptor (mpl)
- C-MPL
- c-mpl
- c-mpl-I
- c-mpl-II
- CD110
- hlb219
- MPL
- mpll
- MPLV
- THCYT2
- TPO-R
- TPOR
- tpor
- tpor.b
Gene-IDs for different species
Protein level used designations for MPL
- TPO-R
- myeloproliferative leukemia protein
- proto-oncogene c-Mpl
- thrombopoietin receptor
- myeloproliferative leukemia virus oncogene
- thrombopoietin receptor-like
- cytokine receptor
- myeloproliferative leukemia virus oncogene, like
- thrombopoietin receptor c-mpl
Proteomics products related to MPL Gene
Other products related to MPL such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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