Nemo-Like Kinase (Nemo-Like Kinase, NLK)
Short Description: Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK- SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs). Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1 (By similarity).
More information related to gene Nemo-Like Kinase.
More information related to gene Nemo-Like Kinase.
Products related to Nemo-Like Kinase Gene:
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55 results
OriGene rr216856
ORF
PExp
Mammalian Expression Vector
pCMV6-Entry
Kanamycin
CMV Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Nemo-Like Kinase (NLK)
- Species:
- Rat
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-Entry
- Resistance Gene:
- Kanamycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN5405961
$534.60
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 21 to 22 Business Days
OriGene rc208723l2
ORF
PExp
Lentiviral Vector
pLenti-C-mGFP
Chloramphenicol
CMV Promoter
GFP tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Nemo-Like Kinase (NLK)
- NCBI Accession:
- NM_016231,NP_057315
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-C-mGFP
- Resistance Gene:
- Chloramphenicol
- Promoter:
- CMV Promoter
- Fusion Tag:
- GFP tag
- Expression:
- Transient
Catalog No. ABIN5405962
$783.09
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 21 to 22 Business Days
OriGene rc208723l1
ORF
PExp
Lentiviral Vector
pLenti-C-Myc-DDK
Chloramphenicol
CMV Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Nemo-Like Kinase (NLK)
- NCBI Accession:
- NM_016231,NP_057315
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-C-Myc-DDK
- Resistance Gene:
- Chloramphenicol
- Promoter:
- CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN5405963
$783.09
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 8 to 11 Business Days
ORF
Clon
Gateway Cloning Vector
pDONR223
Spectinomycin
unconjugated
Catalog No. ABIN5320425
$215.19
Plus shipping costs $50.00
2 μg
Shipping to:
United States
Delivery in 15 to 19 Business Days
ORF
PExp
Mammalian Expression Vector
pcDNA3.1+C-(K)-DYK
Ampicillin
CMV Promoter
DYKDDDDK Tag
Transient
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Nemo-Like Kinase (NLK)
- NCBI Accession:
- NM_016231
- Gene ID:
- 51701 (Human, NLK)
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pcDNA3.1+C-(K)-DYK
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- DYKDDDDK Tag
- Expression:
- Transient, Stable
Catalog No. ABIN4926565
$379.00
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 6 to 9 Business Days
Synonyms and alternative names related to Nemo-Like Kinase
- glucose-6-phosphate isomerase (Gpi)
- nemo like kinase (NLK)
- nemo like kinase (Nlk)
- nemo-like kinase, type 1 (nlk1)
- nemo-like kinase L homeolog (nlk.L)
- nemo like kinase (nlk)
- Nemo-Like kinase (nemo-like)
- nemo-like kinase (nlk)
- AI194375
- Amf
- Gpi1
- nemo-like
- nlk
- NLK
- nlk1
- nlk2
- nlkb
- RGD1561602
- Xnlk
- zgc:111875
Gene-IDs for different species
Protein level used designations for Nemo-Like Kinase
- NLK
- PGI
- PHI
- autocrine motility factor
- glucose phosphate isomerase
- neuroleukin
- phosphoglucose isomerase
- phosphohexose isomerase
- serine/threonine-protein kinase NLK
- nemo-like kinase
- serine/threonine protein kinase NLK
- nemo like kinase b
- nemo-like kinase 2
- Nemo-like kinase
- Serine/threonine-protein kinase NLK
- nemo like kinase
- Nemo-Like kinase
- serine/threonine-protein kinase NLK-like
Proteomics products related to Nemo-Like Kinase Gene
Other products related to Nemo-Like Kinase such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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