PLAU (Plasminogen Activator, Urokinase, PLAU)
Short Description: This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009].
More information related to gene PLAU.
More information related to gene PLAU.
Products related to PLAU Gene:
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OriGene sr303553
RNAi
PLAU
Species: Human
HPLC purified
- Application:
- RNA Interference
- Gene:
- Plasminogen Activator, Urokinase
- Species:
- Human
- Purification:
- HPLC purified
Catalog No. ABIN3343330
$512.82
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 4 to 9 Business Days
Synonyms and alternative names related to PLAU
- plasminogen activator, urokinase (PLAU)
- urokinase-type plasminogen activator (CpipJ_CPIJ002131)
- urokinase-type plasminogen activator (CpipJ_CPIJ006543)
- urokinase-type plasminogen activator (CpipJ_CPIJ013396)
- urokinase-type plasminogen activator (CpipJ_CPIJ013623)
- plasminogen activator, urokinase (Plau)
- ATF
- BDPLT5
- PLAU
- QPD
- u-PA
- UPA
- uPA
- UPAM
- URK
Gene-IDs for different species
Protein level used designations for PLAU
- urokinase-type plasminogen activator
- U-plasminogen activator
- uPA
- plasminogen activator, urokinase
- plasminogen activator, urinary
- Urinary plasminogen activator, urokinase
- urokinase plasminogen activator preproprotein
Proteomics products related to PLAU Gene
Other products related to PLAU such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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