PPP4C (Protein Phosphatase 4, Catalytic Subunit, PPP4C)
Short Description: Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
More information related to gene PPP4C.
More information related to gene PPP4C.
Products related to PPP4C Gene:
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OriGene sr303697
RNAi
PPP4C
Species: Human
HPLC purified
- Application:
- RNA Interference
- Gene:
- Protein Phosphatase 4, Catalytic Subunit
- Species:
- Human
- Purification:
- HPLC purified
Catalog No. ABIN3343473
$512.82
Plus shipping costs $50.00
1 kit
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United States
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Synonyms and alternative names related to PPP4C
- protein phosphatase 4 catalytic subunit (ppp4c)
- protein phosphatase 4, catalytic subunit a (ppp4ca)
- protein phosphatase 4 catalytic subunit (PPP4C)
- protein phosphatase 4, catalytic subunit (Ppp4c)
- protein phosphatase 4 catalytic subunit S homeolog (ppp4c.S)
- 1110002D08Rik
- AU016079
- gc:56413
- MGC75928
- pp4
- PP4
- pp4c
- PP4C
- PP4C-A
- pph3
- PPH3
- PPP4
- ppp4c
- ppx
- PPX
- Ppx
- wu:fd05e08
- zgc:56413
Gene-IDs for different species
Protein level used designations for PPP4C
- protein phosphatase 4, catalytic subunit
- catalytic subunit
- serine/threonine-protein phosphatase 4 catalytic subunit A
- PP-X
- protein phosphatase 4 (formerly X), catalytic subunit
- protein phosphatase X, catalytic subunit
- serine/threonine-protein phosphatase 4 catalytic subunit
- PP4C
- pp4
- protein phosphatase X
Proteomics products related to PPP4C Gene
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