PSMC1 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 1, PSMC1)
Short Description: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. [provided by RefSeq, Jul 2008].
More information related to gene PSMC1.
More information related to gene PSMC1.
Products related to PSMC1 Gene:
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ORF
Clon
Gateway Cloning Vector
pDONR223
Spectinomycin
unconjugated
Catalog No. ABIN5322209
$215.19
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2 μg
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Synonyms and alternative names related to PSMC1
- protease (prosome, macropain) 26S subunit, ATPase 1 (Psmc1)
- proteasome 26S subunit, ATPase 1 (PSMC1)
- proteasome 26S subunit, ATPase 1 (Psmc1)
- AI325227
- P26s4
- P26S4
- p56
- S4
- s4
Gene-IDs for different species
Protein level used designations for PSMC1
- 26S protease regulatory subunit 4
- 26S proteasome AAA-ATPase subunit RPT2
- proteasome 26S subunit ATPase 1
- proteasome 26S ATPase subunit 1
- proteasome 26S subunit, ATPase, 1
- P26s4
- peptidase (prosome, macropain) 26S subunit, ATPase 1
- protease (prosome, macropain) 26S subunit, ATPase 1
- 26S ATPase complex subunit 4
Proteomics products related to PSMC1 Gene
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