PYGL (phosphorylase, Glycogen, Liver, PYGL)
Short Description: This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2011].
More information related to gene PYGL.
More information related to gene PYGL.
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61 results
ORF
Clon
Gateway Cloning Vector
pDONR223
Spectinomycin
unconjugated
Catalog No. ABIN5324183
$237.47
Plus shipping costs $50.00
2 μg
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United States
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Synonyms and alternative names related to PYGL
- glycogen phosphorylase L (PYGL)
- phosphorylase, glycogen, liver (pygl)
- phosphorylase, glycogen, liver S homeolog (pygl.S)
- liver glycogen phosphorylase (Pygl)
- glycogen phosphorylase L (Pygl)
- GSD6
- zgc:66314
Gene-IDs for different species
Protein level used designations for PYGL
- glycogen phosphorylase, liver form
- liver glycogen phosphorylase
- phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI)
- glycogen storage disease type VI-related protein
- phosphorylase, glycogen; liver
Proteomics products related to PYGL Gene
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