RPSA/Laminin Receptor (Ribosomal Protein SA, RPSA)
Short Description: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. More information related to gene RPSA/Laminin Receptor.
Synonyms and alternative names related to RPSA/Laminin Receptor
40S ribosomal protein SA (rssa)
67kD laminin receptor (rpsa)
ribosomal protein SA (RPSA)
ribosomal protein SA (Rpsa)
ribosomal protein SA (rpsa)
40S ribosomal protein SA (LOC100144340)
37LRP
67kDa
67LR
67lr
AL022858
DMRT1
LAMBR
LamR
lamR
Lamr
LamR1
LAMR1
Lamr1
lamr1
Lamrl1
LBP
LBP/p40
LRP
LRP/LR
MLR
NEM/1CHD4
p40
P40
P40-3
P40-8
rpsa
RPSA
SA
zgc:55831
zgc:77824
Gene-IDs for different species
Protein level used designations for RPSA/Laminin Receptor
37 kDa laminin receptor
37/67 kDa laminin receptor
67 kDa laminin receptor
Laminin receptor 1
Laminin-binding protein precursor p40
ribosomal protein SA
40S ribosomal protein SA
laminin-binding protein precursor p40
37LRP
67LR
LBP/p40
LRP/LR
lamR
colon carcinoma laminin-binding protein
laminin receptor 1 (67kD, ribosomal protein SA)
multidrug resistance-associated protein MGr1-Ag
37 kDa oncofetal antigen
OFA/iLRP
P40-3, functional
P40-8, functional
laminin receptor 1 (ribosomal protein SA)
37kD Laminin receptor
laminin receptor 1
laminin receptor 1 (ribosomal protein SA, 67 kDA)
ribosomal protein SA pseudogene
laminin receptor
Proteomics products related to RPSA/Laminin Receptor Gene
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