SMURF2 (SMAD Specific E3 Ubiquitin Protein Ligase 2, SMURF2)
Short Description: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level (By similarity).
More information related to gene SMURF2.
More information related to gene SMURF2.
Products related to SMURF2 Gene:
Recommended next Filters:
56 results
OriGene tg705633
shRNA
RNAi
Retroviral Vector
pGFP-V-RS
Kanamycin
U6 Promoter
GFP tag
Transient
1
- Type:
- shRNA
- Application:
- RNA Interference
- Gene:
- SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
- Species:
- Rat
- Vector type:
- Retroviral Vector
- Vector backbone:
- pGFP-V-RS
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter
- Fusion Tag:
- GFP tag
- Expression:
- Transient, Stable
Catalog No. ABIN3499854
$707.85
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
OriGene tr705633
shRNA
RNAi
Retroviral Vector
pRS
Ampicillin
U6 Promoter
unconjugated
Transient
1
- Type:
- shRNA
- Application:
- RNA Interference
- Gene:
- SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
- Species:
- Rat
- Vector type:
- Retroviral Vector
- Vector backbone:
- pRS
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter
- Expression:
- Transient, Stable
Catalog No. ABIN3439041
$874.17
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
OriGene sr419799
RNAi
SMURF2
Species: Mouse
HPLC purified
- Application:
- RNA Interference
- Gene:
- SMAD Specific E3 Ubiquitin Protein Ligase 2
- Species:
- Mouse
- Purification:
- HPLC purified
Catalog No. ABIN3262976
$512.82
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
OriGene sr506356
RNAi
SMURF2
Species: Rat
HPLC purified
- Application:
- RNA Interference
- Gene:
- SMAD Specific E3 Ubiquitin Protein Ligase 2
- Species:
- Rat
- Purification:
- HPLC purified
Catalog No. ABIN3355988
$512.82
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
OriGene kn516361
gRNA + Cas9
GEEN
Mammalian Expression Vector
pCas-Guide
Ampicillin
U6 Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- gRNA + Cas9
- Application:
- Genome Editing with Engineered Nucleases
- Gene:
- SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
- Species:
- Mouse
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCas-Guide
- Resistance Gene:
- Ampicillin
- Promoter:
- U6 Promoter, Enhanced CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN3224001
$1,640.43
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 21 to 22 Business Days
OriGene kn210866
gRNA + Cas9
GEEN
Mammalian Expression Vector
pCas-Guide
Ampicillin
U6 Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- gRNA + Cas9
- Application:
- Genome Editing with Engineered Nucleases
- Gene:
- SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCas-Guide
- Resistance Gene:
- Ampicillin
- Promoter:
- U6 Promoter, Enhanced CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN3224000
$1,640.43
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 10 to 13 Business Days
OriGene rn206642
cDNA
PExp
Mammalian Expression Vector
pCMV6-Entry
Kanamycin
Enhanced CMV Promoter
unconjugated
Transient
1
- Type:
- cDNA
- Application:
- Protein Expression
- Gene:
- SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
- NCBI Accession:
- NM_001107061,NP_001100531
- Species:
- Rat
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-Entry
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Neomycin
- Promoter:
- Enhanced CMV Promoter
- Expression:
- Transient
Catalog No. ABIN3371377
$746.46
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 31 to 32 Business Days
OriGene mc221302
cDNA
PExp
Mammalian Expression Vector
pCMV6-Entry
Kanamycin
Enhanced CMV Promoter
unconjugated
Transient
1
- Type:
- cDNA
- Application:
- Protein Expression
- Gene:
- SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
- NCBI Accession:
- NM_025481,NP_079757
- Species:
- Mouse
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-Entry
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Neomycin
- Promoter:
- Enhanced CMV Promoter
- Expression:
- Transient
Catalog No. ABIN3371376
$746.46
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 36 to 37 Business Days
OriGene sc112475
cDNA
PExp
Mammalian Expression Vector
pCMV6-XL6
Ampicillin
Enhanced CMV Promoter
unconjugated
Transient
1
- Type:
- cDNA
- Application:
- Protein Expression
- Gene:
- SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
- NCBI Accession:
- NM_022739,NP_073576
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-XL6
- Resistance Gene:
- Ampicillin
- Promoter:
- Enhanced CMV Promoter, SP6 Promoter
- Expression:
- Transient
Catalog No. ABIN3393814
$679.14
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 4 to 9 Business Days
ORF
PExp
Mammalian Expression Vector
pcDNA3.1+C-(K)-DYK
Ampicillin
CMV Promoter
DYKDDDDK Tag
Transient
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
- NCBI Accession:
- NM_022739
- Gene ID:
- 64750 (Human, SMURF2)
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pcDNA3.1+C-(K)-DYK
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- DYKDDDDK Tag
- Expression:
- Transient, Stable
Catalog No. ABIN4935132
$559.00
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 4 to 7 Business Days
Synonyms and alternative names related to SMURF2
- SMAD specific E3 ubiquitin protein ligase 2 (SMURF2)
- SMAD specific E3 ubiquitin protein ligase 2 (smurf2)
- SMAD specific E3 ubiquitin protein ligase 2 (Smurf2)
- SMAD specific E3 ubiquitin protein ligase 2 S homeolog (smurf2.S)
- 2810411E22Rik
- AI558114
- AI649275
- RGD1310067
- SMURF2
- wu:fb82a11
- wu:fc41c02
Gene-IDs for different species
Protein level used designations for SMURF2
- SMAD specific E3 ubiquitin protein ligase 2
- E3 ubiquitin-protein ligase SMURF2-like
- e3 ubiquitin-protein ligase SMURF2-like
- E3 ubiquitin ligase SMURF2
- E3 ubiquitin-protein ligase SMURF2
- SMAD ubiquitination regulatory factor 2
- SMAD-specific E3 ubiquitin-protein ligase 2
- hSMURF2
- E3 ubiquitin ligase Smurf2
Proteomics products related to SMURF2 Gene
Other products related to SMURF2 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
You are here:
