SMURF2 (SMAD Specific E3 Ubiquitin Protein Ligase 2, SMURF2)
Short Description: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level (By similarity).
More information related to gene SMURF2.
More information related to gene SMURF2.
Products related to SMURF2 Gene:
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56 results
OriGene rc210866l1
ORF
PExp
Lentiviral Vector
pLenti-C-Myc-DDK
Chloramphenicol
CMV Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
- NCBI Accession:
- NM_022739,NP_073576
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-C-Myc-DDK
- Resistance Gene:
- Chloramphenicol
- Promoter:
- CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN5446716
$975.15
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 8 to 11 Business Days
OriGene rr206642
ORF
PExp
Mammalian Expression Vector
pCMV6-Entry
Kanamycin
CMV Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
- NCBI Accession:
- NM_001107061,NP_001100531
- Species:
- Rat
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-Entry
- Resistance Gene:
- Kanamycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN5446713
$583.11
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 8 to 11 Business Days
OriGene rc210866
ORF
PExp
Mammalian Expression Vector
pCMV6-Entry
Kanamycin
CMV Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
- NCBI Accession:
- NM_022739,NP_073576
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-Entry
- Resistance Gene:
- Kanamycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN5446712
$678.15
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 8 to 11 Business Days
OriGene rg210866
ORF
PExp
Mammalian Expression Vector
pCMV6-AC-GFP
Ampicillin
CMV Promoter
GFP tag
Stable
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-AC-GFP
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- GFP tag
- Expression:
- Stable, Transient
Catalog No. ABIN5446711
$781.11
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 8 to 11 Business Days
OriGene rc210866l2
ORF
PExp
Lentiviral Vector
pLenti-C-mGFP
Chloramphenicol
CMV Promoter
GFP tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- SMAD Specific E3 Ubiquitin Protein Ligase 2 (SMURF2)
- NCBI Accession:
- NM_022739,NP_073576
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-C-mGFP
- Resistance Gene:
- Chloramphenicol
- Promoter:
- CMV Promoter
- Fusion Tag:
- GFP tag
- Expression:
- Transient
Catalog No. ABIN5446714
$975.15
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 21 to 22 Business Days
OriGene sr312096
RNAi
SMURF2
Species: Human
HPLC purified
2
- Application:
- RNA Interference
- Gene:
- SMAD Specific E3 Ubiquitin Protein Ligase 2
- Species:
- Human
- Purification:
- HPLC purified
Catalog No. ABIN3288126
$512.82
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 4 to 9 Business Days
Synonyms and alternative names related to SMURF2
- SMAD specific E3 ubiquitin protein ligase 2 (SMURF2)
- SMAD specific E3 ubiquitin protein ligase 2 (smurf2)
- SMAD specific E3 ubiquitin protein ligase 2 (Smurf2)
- SMAD specific E3 ubiquitin protein ligase 2 S homeolog (smurf2.S)
- 2810411E22Rik
- AI558114
- AI649275
- RGD1310067
- SMURF2
- wu:fb82a11
- wu:fc41c02
Gene-IDs for different species
Protein level used designations for SMURF2
- SMAD specific E3 ubiquitin protein ligase 2
- E3 ubiquitin-protein ligase SMURF2-like
- e3 ubiquitin-protein ligase SMURF2-like
- E3 ubiquitin ligase SMURF2
- E3 ubiquitin-protein ligase SMURF2
- SMAD ubiquitination regulatory factor 2
- SMAD-specific E3 ubiquitin-protein ligase 2
- hSMURF2
- E3 ubiquitin ligase Smurf2
Proteomics products related to SMURF2 Gene
Other products related to SMURF2 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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