Short Description: Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]. More information related to gene Thyroglobulin.
Synonyms and alternative names related to Thyroglobulin
thyroglobulin (TG)
thyroglobulin (tg)
thyroglobulin (LOC701526)
thyroglobulin (LOC701756)
thyroglobulin (LOC100434297)
thyroglobulin (Tg)
AITD3
cb717
cog
TG
TGN
Tgn
Gene-IDs for different species
Protein level used designations for Thyroglobulin
thyroglobulin
thyroglobulin-like
congenital goiter
hereditary goitre
Proteomics products related to Thyroglobulin Gene
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