Titin (Titin, TTN)
Short Description: This gene encodes a large abundant protein of striated muscle. The product of this gene is divided into two regions, a N-terminal I-band and a C-terminal A-band. The I-band, which is the elastic part of the molecule, contains two regions of tandem immunoglobulin domains on either side of a PEVK region that is rich in proline, glutamate, valine and lysine. The A-band, which is thought to act as a protein-ruler, contains a mixture of immunoglobulin and fibronectin repeats, and possesses kinase activity. An N-terminal Z-disc region and a C-terminal M-line region bind to the Z-line and M-line of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle cells. It has also been identified as a structural protein for chromosomes. Alternative splicing of this gene results in multiple transcript variants. Considerable variability exists in the I-band, the M-line and the Z-disc regions of titin. Variability in the I-band region contributes to the differences in elasticity of different titin isoforms and, therefore, to the differences in elasticity of different muscle types. Mutations in this gene are associated with familial hypertrophic cardiomyopathy 9, and autoantibodies to titin are produced in patients with the autoimmune disease scleroderma. [provided by RefSeq, Feb 2012].
More information related to gene Titin.
More information related to gene Titin.
Products related to Titin Gene:
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24 results
OriGene tl517278
shRNA
RNAi
Lentiviral Vector
pGFP-C-shLenti
Chloramphenicol
U6 Promoter
GFP tag
Transient
1
- Type:
- shRNA
- Application:
- RNA Interference
- Gene:
- Titin (TTN)
- Species:
- Mouse
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pGFP-C-shLenti
- Resistance Gene:
- Chloramphenicol
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter
- Fusion Tag:
- GFP tag
- Expression:
- Transient, Stable
Catalog No. ABIN3529861
$1,002.87
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
OriGene kn416240
gRNA + Cas9
GEEN
Mammalian Expression Vector
pCas-Guide
Ampicillin
U6 Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- gRNA + Cas9
- Application:
- Genome Editing with Engineered Nucleases
- Gene:
- Titin (TTN)
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCas-Guide
- Resistance Gene:
- Ampicillin
- Promoter:
- U6 Promoter, Enhanced CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN3259140
$1,640.43
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 21 to 22 Business Days
OriGene sr423733
RNAi
TTN
Species: Mouse
HPLC purified
- Application:
- RNA Interference
- Gene:
- Titin
- Species:
- Mouse
- Purification:
- HPLC purified
Catalog No. ABIN3350571
$512.82
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
OriGene sr304963
RNAi
TTN
Species: Human
HPLC purified
- Application:
- RNA Interference
- Gene:
- Titin
- Species:
- Human
- Purification:
- HPLC purified
Catalog No. ABIN3344733
$512.82
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 4 to 9 Business Days
Synonyms and alternative names related to Titin
- titin (TTN)
- titin (Ttn)
- titin (titin)
- titin (TTNLOC100620261)
- 1100001C23Rik
- 2310036G12Rik
- 2310057K23Rik
- 2310074I15Rik
- AF006999
- AV006427
- CMD1G
- CMH9
- CMPD4
- D330041I19Rik
- D830007G01Rik
- EOMFC
- HMERF
- L56
- LGMD2J
- mdm
- MYLK5
- shru
- TMD
- UNC-22
Gene-IDs for different species
Protein level used designations for Titin
- connectin
- rhabdomyosarcoma antigen MU-RMS-40.14
- titin protein homolog
- titin
Proteomics products related to Titin Gene
Other products related to Titin such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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