Short Description: This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome. [provided by RefSeq, Jul 2008]. More information related to gene Ubiquitin B.
Synonyms and alternative names related to Ubiquitin B
ubiquitin B (UBB)
ubiquitin B (Ubb)
ubiquitin C (UBC)
ubiquitin B (ubb)
AL033289
im:6892314
Rps27a
si:ch211-202a12.3
Uba52
UBB
Ubb2
Ubc
UBC
ubc
Ubi-p63E
Ubiquitin
zgc:172187
zUBC
Gene-IDs for different species
Protein level used designations for Ubiquitin B
polyubiquitin B
polyubiquitin-B
polyubiquitin
ubiquitin C
Proteomics products related to Ubiquitin B Gene
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