Uromodulin (Uromodulin, UMOD)
Short Description: This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq, Jul 2008].
More information related to gene Uromodulin.
More information related to gene Uromodulin.
Products related to Uromodulin Gene:
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62 results
ORF
PExp
Mammalian Expression Vector
pcDNA3.1+C-(K)-DYK
Ampicillin
CMV Promoter
DYKDDDDK Tag
Transient
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Uromodulin (UMOD)
- NCBI Accession:
- NM_001008389
- Gene ID:
- 7369 (Human, UMOD)
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pcDNA3.1+C-(K)-DYK
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- DYKDDDDK Tag
- Expression:
- Transient, Stable
Catalog No. ABIN4921543
OriGene sr305033
RNAi
UMOD
Species: Human
HPLC purified
- Application:
- RNA Interference
- Gene:
- Uromodulin
- Species:
- Human
- Purification:
- HPLC purified
Catalog No. ABIN3344803
$512.82
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
Synonyms and alternative names related to Uromodulin
- uromodulin (UMOD)
- uromodulin (Umod)
- ADMCKD2
- FJHN
- HNFJ
- HNFJ1
- MCKD2
- THGP
- THP
- urehr4
Gene-IDs for different species
Protein level used designations for Uromodulin
- uromodulin
- Tamm-Horsfall urinary glycoprotein
- uromucoid
- THP
- tamm-Horsfall urinary glycoprotein
- uromodulin (uromucoid, Tamm-Horsfall glycoprotein)
- Urmodulin (Tamm-Horsfall protein)
- uromucoid, human : Tamm-Horsfall glycoprotein
Proteomics products related to Uromodulin Gene
Other products related to Uromodulin such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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