APH1A (Anterior Pharynx Defective 1 Homolog A (C. Elegans), APH1A)
Short Description: This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq, Aug 2011].
More information related to gene APH1A.
More information related to gene APH1A.
Products related to APH1A Gene:
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ORF
Clon
Gateway Cloning Vector
pDONR223
Spectinomycin
unconjugated
Catalog No. ABIN5311921
$204.05
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2 μg
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Synonyms and alternative names related to APH1A
- aph-1 homolog A, gamma-secretase subunit (APH1A)
- aph-1 homolog A, gamma secretase subunit L homeolog (aph1a.L)
- aph-1 homolog A, gamma secretase subunit (Aph1a)
- anterior pharynx defective 1 homolog A (C. elegans) (APH1A)
- aph1 homolog A, gamma secretase subunit (Aph1a)
- acylamino-acid-releasing enzyme-like (LOC100219182)
- 6530402N02Rik
- APH-1
- APH-1A
- APH-1a
- CGI-78
- RGD1311546
Gene-IDs for different species
Protein level used designations for APH1A
- anterior pharynx defective 1 homolog A
- aph-1alpha
- gamma-secretase subunit APH-1A
- presenilin-stabilization factor
- anterior pharynx defective 1a homolog
- N-acylaminoacyl-peptide hydrolase
Proteomics products related to APH1A Gene
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