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APH1A (Anterior Pharynx Defective 1 Homolog A (C. Elegans), APH1A)

Short Description: This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq, Aug 2011].
More information related to gene APH1A.

Products related to APH1A Gene:

91 results :

Human APH1A ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A)
Species:
Human
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5720957
Datasheet
Catalog No. ABIN5720957
Type:
ORF
Application:
Cloning
Gene:
Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A)
Species:
Human
Synonyms:
APH1A, aph1a.L, Aph1a, LOC100219182
Insert length:
744 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Human APH1A ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A)
Species:
Human
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5720958
Datasheet
Catalog No. ABIN5720958
Type:
ORF
Application:
Cloning
Gene:
Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A)
Species:
Human
Synonyms:
APH1A, aph1a.L, Aph1a, LOC100219182
Insert length:
798 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Human APH1A ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A)
Species:
Human
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5720959
Datasheet
Catalog No. ABIN5720959
Type:
ORF
Application:
Cloning
Gene:
Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A)
Species:
Human
Synonyms:
APH1A, aph1a.L, Aph1a, LOC100219182
Insert length:
798 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Human APH1A cDNA Clone in Mammalian Expression Vector (HA tag)
cDNA PExp Mammalian Expression Vector pPM-C-HA Kanamycin CMV Promoter HA tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Catalog No. ABIN4472126
Datasheet
Catalog No. ABIN4472126
Type:
cDNA
Application:
Protein Expression
Gene:
Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A)
Species:
Human
Synonyms:
APH1A, aph1a.L, Aph1a, LOC100219182
Insert length:
744 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human APH1A cDNA Clone in Mammalian Expression Vector (HA tag)
cDNA PExp Mammalian Expression Vector pPM-C-HA Kanamycin CMV Promoter HA tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Catalog No. ABIN4472125
Datasheet
Catalog No. ABIN4472125
Type:
cDNA
Application:
Protein Expression
Gene:
Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A)
Species:
Human
Synonyms:
APH1A, aph1a.L, Aph1a, LOC100219182
Insert length:
744 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human APH1A cDNA Clone in Mammalian Expression Vector (HA tag)
cDNA PExp Mammalian Expression Vector pPM-C-HA Kanamycin CMV Promoter HA tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Catalog No. ABIN4472124
Datasheet
Catalog No. ABIN4472124
Type:
cDNA
Application:
Protein Expression
Gene:
Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A)
Species:
Human
Synonyms:
APH1A, aph1a.L, Aph1a, LOC100219182
Insert length:
744 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Rat APH1A CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A)
NCBI Accession:
NM_001014255
Species:
Rat
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5083860
Datasheet
Catalog No. ABIN5083860
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A)
NCBI Accession:
NM_001014255
Species:
Rat
Synonyms:
APH1A, aph1a.L, Aph1a, LOC100219182
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Aph1a
Format:
Viral Particles
Storage:
-80 °C
Human APH1A CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A)
NCBI Accession:
NM_001077628
Species:
Human
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5083856
Datasheet
Catalog No. ABIN5083856
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A)
NCBI Accession:
NM_001077628
Species:
Human
Synonyms:
APH1A, aph1a.L, Aph1a, LOC100219182
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of APH1A
Format:
Viral Particles
Storage:
-80 °C
Mouse APH1A CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A)
NCBI Accession:
NM_146104
Species:
Mouse
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5083858
Datasheet
Catalog No. ABIN5083858
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A)
NCBI Accession:
NM_146104
Species:
Mouse
Synonyms:
APH1A, aph1a.L, Aph1a, LOC100219182
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Aph1a
Format:
Viral Particles
Storage:
-80 °C
Human APH1A cDNA Clone in Bacterial Expression Vector (His-GST)
cDNA Clon Bacterial Expression Vector pPB-His-GST Kanamycin T7 Promoter His-GST Transient
Type:
cDNA
Application:
Cloning
Gene:
Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A)
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Catalog No. ABIN4826578
Datasheet
Catalog No. ABIN4826578
Type:
cDNA
Application:
Cloning
Gene:
Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A)
Species:
Human
Synonyms:
APH1A, aph1a.L, Aph1a, LOC100219182
Insert length:
744 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Sequencing Primer:
  • GST Forward primer: 5'-CACGTTTGGTGGTGGCGAC3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
  • Type
    • Plasmid
    • Primer
  • Supplier
    • antibodies-online
    • OriGene
    • GenScript
    • ProteoGenix
  • Reactivity
    • Human
    • Mouse
    • Rat
  • Application
    • Protein Expression (PExp)
    • Cloning (Clon)
    • Genome Editing with Engineered Nucleases (GEEN)
    • RNA Interference (RNAi)
  • Conjugate
    • Un-conjugated
    • GFP tag
    • His tag
    • Myc-DYKDDDDK Tag
    • HA tag
    • His-GST
    • His-MBP
    • DYKDDDDK Tag
    • RFP tag
  • Vector Backbone
    • pCMV6-Entry
    • pLenti-U6-sgRNA-PGK-Neo
    • pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
    • pORF
    • pPB-His-GST
    • pPB-His-MBP
    • pPB-N-His
    • pPM-C-HA
    • pPM-C-His
    • pCMV6-AC-GFP
    • pLenti-C-Myc-DDK
    • pLenti-C-mGFP
    • pcDNA3.1+C-(K)-DYK
    • pDONR223
    • pGFP-C-shLenti
    • pGFP-V-RS
    • pRS
    • pCMV6-AC
    • pCas-Guide
    • pRFP-C-RS
    • pCMV6-XL4
  • Vector
    • Mammalian Expression Vector
    • Lentiviral Vector
    • Bacterial Expression Vector
    • Retroviral Vector
    • Cloning Vector
    • Gateway Cloning Vector
  • Insert
    • cDNA
    • ORF
    • shRNA
    • gRNA + Cas9
    • gRNA
  • Type of Oligonucleotide
    • siRNA Oligo
  • Bacterial Resistance
    • Kanamycin
    • Ampicillin
    • Chloramphenicol
    • Spectinomycin
  • Expression Type
    • Transient
    • Stable
  • Selectable Marker
    • Neomycin
    • Puromycin
  • Promoter
    • CMV Promoter
    • U6 Promoter
    • T7 Promoter
    • Enhanced CMV Promoter
    • PGK Promoter
    • SFFV Promoter
  • Format
    • Lyophilized
    • Liquid
    • Viral Particles

Synonyms and alternative names related to APH1A

  • aph-1 homolog A, gamma-secretase subunit (APH1A)
  • aph-1 homolog A, gamma secretase subunit L homeolog (aph1a.L)
  • aph-1 homolog A, gamma secretase subunit (Aph1a)
  • anterior pharynx defective 1 homolog A (C. elegans) (APH1A)
  • aph1 homolog A, gamma secretase subunit (Aph1a)
  • acylamino-acid-releasing enzyme-like (LOC100219182)
  • 6530402N02Rik
  • APH-1
  • APH-1A
  • APH-1a
  • CGI-78
  • RGD1311546

Gene-IDs for different species

Protein level used designations for APH1A

  • anterior pharynx defective 1 homolog A
  • aph-1alpha
  • gamma-secretase subunit APH-1A
  • presenilin-stabilization factor
  • anterior pharynx defective 1a homolog
  • N-acylaminoacyl-peptide hydrolase
Other products related to APH1A such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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