PIKFYVE (phosphoinositide Kinase, FYVE Finger Containing, PIKFYVE)
Short Description: Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve\; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD)\; an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010].
More information related to gene PIKFYVE.
More information related to gene PIKFYVE.
Products related to PIKFYVE Gene:
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43 results
OriGene rc222618
ORF
PExp
Mammalian Expression Vector
pCMV6-Entry
Kanamycin
CMV Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE)
- NCBI Accession:
- NM_015040,NP_055855
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-Entry
- Resistance Gene:
- Kanamycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN5454664
$1,884.96
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 61 to 62 Business Days
OriGene rc230258
ORF
PExp
Mammalian Expression Vector
pCMV6-Entry
Kanamycin
CMV Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE)
- NCBI Accession:
- NM_001178000,NP_001171471
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-Entry
- Resistance Gene:
- Kanamycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN5454665
$286.11
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 8 to 11 Business Days
OriGene sr316347
RNAi
PIKFYVE
Species: Human
HPLC purified
- Application:
- RNA Interference
- Gene:
- phosphoinositide Kinase, FYVE Finger Containing
- Species:
- Human
- Purification:
- HPLC purified
Catalog No. ABIN3313346
$512.82
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
Synonyms and alternative names related to PIKFYVE
- phosphoinositide kinase, FYVE finger containing (pikfyve)
- phosphoinositide kinase, FYVE-type zinc finger containing (PIKFYVE)
- phosphoinositide kinase, FYVE type zinc finger containing (Pikfyve)
- phosphoinositide kinase, FYVE-type zinc finger containing (Pikfyve)
- 5230400C17Rik
- CFD
- FAB1
- fab1-like
- p235
- PIP5K
- Pip5k
- pip5k3
- PIP5K3
- Pip5k3
- Pipk5k3
- PipkIII
- wu:fo93c03
- ZFYVE29
Gene-IDs for different species
Protein level used designations for PIKFYVE
- 1-phosphatidylinositol-3-phosphate 5-kinase
- phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III
- 1-phosphatidylinositol 3-phosphate 5-kinase
- PIPkin-III
- phosphatidylinositol 3-phosphate 5-kinase type III
- type III PIP kinase
- zinc finger, FYVE domain containing 29
- FYVE finger-containing phosphoinositide kinase
- PtdIns(4)P-5-kinase
- phosphatidylinositol-3-phosphate 5-kinase type III
- phosphatidylinositol-4-phosphate 5-kinase, type III
Proteomics products related to PIKFYVE Gene
Other products related to PIKFYVE such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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