PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae), PMS2)
Short Description: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2- MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. {ECO:0000269|PubMed:16873062, ECO:0000269|PubMed:18206974, ECO:0000269|PubMed:23709753}.
More information related to gene PMS2.
More information related to gene PMS2.
Products related to PMS2 Gene:
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56 results
OriGene rg210880
ORF
PExp
Mammalian Expression Vector
pCMV6-AC-GFP
Ampicillin
CMV Promoter
GFP tag
Stable
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2)
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-AC-GFP
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- GFP tag
- Expression:
- Stable, Transient
Catalog No. ABIN5424582
$1,370.16
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 21 to 22 Business Days
OriGene rc210880
ORF
PExp
Mammalian Expression Vector
pCMV6-Entry
Kanamycin
CMV Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2)
- NCBI Accession:
- NM_000535,NP_000526
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-Entry
- Resistance Gene:
- Kanamycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN5424583
$1,172.16
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 8 to 11 Business Days
OriGene rr206498
ORF
PExp
Mammalian Expression Vector
pCMV6-Entry
Kanamycin
CMV Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2)
- NCBI Accession:
- NM_001105908,NP_001099378
- Species:
- Rat
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-Entry
- Resistance Gene:
- Kanamycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN5424584
$549.45
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 21 to 22 Business Days
OriGene rc210880l1
ORF
PExp
Lentiviral Vector
pLenti-C-Myc-DDK
Chloramphenicol
CMV Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2)
- NCBI Accession:
- NM_000535,NP_000526
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-C-Myc-DDK
- Resistance Gene:
- Chloramphenicol
- Promoter:
- CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN5424587
$1,469.16
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 8 to 11 Business Days
OriGene rc210880l2
ORF
PExp
Lentiviral Vector
pLenti-C-mGFP
Chloramphenicol
CMV Promoter
GFP tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2)
- NCBI Accession:
- NM_000535,NP_000526
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-C-mGFP
- Resistance Gene:
- Chloramphenicol
- Promoter:
- CMV Promoter
- Fusion Tag:
- GFP tag
- Expression:
- Transient
Catalog No. ABIN5424585
$1,469.16
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 21 to 22 Business Days
OriGene sr303601
RNAi
PMS2
Species: Human
HPLC purified
- Application:
- RNA Interference
- Gene:
- PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae)
- Species:
- Human
- Purification:
- HPLC purified
Catalog No. ABIN3343378
$512.82
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 4 to 9 Business Days
Synonyms and alternative names related to PMS2
- PMS1 homolog 2, mismatch repair system component (PMS2)
- PMS1 homolog 2, mismatch repair system component (Pms2)
- PMS1 homolog2, mismatch repair system component (Pms2)
- mismatch repair endonuclease PMS2 (LOC463257)
- mismatch repair endonuclease PMS2 (LOC107984056)
- AW555130
- HNPCC4
- PMS2CL
- PMSL2
- Pmsl2
Gene-IDs for different species
Protein level used designations for PMS2
- DNA mismatch repair protein PMS2
- H_DJ0042M02.9
- PMS1 protein homolog 2
- mismatch repair endonuclease PMS2
- PMS2 postmeiotic segregation increased 2
Proteomics products related to PMS2 Gene
Other products related to PMS2 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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