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PMS2 (PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae), PMS2)

Short Description: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2- MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. {ECO:0000269|PubMed:16873062, ECO:0000269|PubMed:18206974, ECO:0000269|PubMed:23709753}.
More information related to gene PMS2.

Products related to PMS2 Gene:

56 results :

Human PMS2 cDNA Clone in Mammalian Expression Vector (HA tag)
cDNA PExp Mammalian Expression Vector pPM-C-HA Kanamycin CMV Promoter HA tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2)
NCBI Accession:
NM_000535
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Catalog No. ABIN4489794
Datasheet
Catalog No. ABIN4489794
Type:
cDNA
Application:
Protein Expression
Gene:
PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2)
NCBI Accession:
NM_000535
Species:
Human
Synonyms:
PMS2, Pms2, LOC463257, LOC107984056
Insert length:
2589 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human PMS2 ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2)
NCBI Accession:
NM_000535
Species:
Human
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5747580
Datasheet
Catalog No. ABIN5747580
Type:
ORF
Application:
Cloning
Gene:
PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2)
NCBI Accession:
NM_000535
Species:
Human
Synonyms:
PMS2, Pms2, LOC463257, LOC107984056
Insert length:
2589 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Rat PMS2 CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2)
NCBI Accession:
NM_001105908
Species:
Rat
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5247613
Datasheet
Catalog No. ABIN5247613
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2)
NCBI Accession:
NM_001105908
Species:
Rat
Synonyms:
PMS2, Pms2, LOC463257, LOC107984056
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Pms2
Format:
Viral Particles
Storage:
-80 °C
Human PMS2 CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2)
NCBI Accession:
NM_000535
Species:
Human
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5247609
Datasheet
Catalog No. ABIN5247609
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2)
NCBI Accession:
NM_000535
Species:
Human
Synonyms:
PMS2, Pms2, LOC463257, LOC107984056
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of PMS2
Format:
Viral Particles
Storage:
-80 °C
Mouse PMS2 CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2)
NCBI Accession:
NM_008886
Species:
Mouse
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5247611
Datasheet
Catalog No. ABIN5247611
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2)
NCBI Accession:
NM_008886
Species:
Mouse
Synonyms:
PMS2, Pms2, LOC463257, LOC107984056
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Pms2
Format:
Viral Particles
Storage:
-80 °C
Mouse PMS2 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2)
NCBI Accession:
NM_008886
Species:
Mouse
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5132152
Datasheet
Catalog No. ABIN5132152
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2)
NCBI Accession:
NM_008886
Species:
Mouse
Synonyms:
PMS2, Pms2, LOC463257, LOC107984056
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Pms2
Format:
Viral Particles
Storage:
-80 °C
Human PMS2 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2)
NCBI Accession:
NM_000535
Species:
Human
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5132150
Datasheet
Catalog No. ABIN5132150
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2)
NCBI Accession:
NM_000535
Species:
Human
Synonyms:
PMS2, Pms2, LOC463257, LOC107984056
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of PMS2
Format:
Viral Particles
Storage:
-80 °C
Rat PMS2 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2)
NCBI Accession:
NM_001105908
Species:
Rat
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5132154
Datasheet
Catalog No. ABIN5132154
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2)
NCBI Accession:
NM_001105908
Species:
Rat
Synonyms:
PMS2, Pms2, LOC463257, LOC107984056
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Pms2
Format:
Viral Particles
Storage:
-80 °C
Human PMS2 cDNA Clone in Bacterial Expression Vector (His-GST)
cDNA Clon Bacterial Expression Vector pPB-His-GST Kanamycin T7 Promoter His-GST Transient
Type:
cDNA
Application:
Cloning
Gene:
PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2)
NCBI Accession:
NM_000535
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Catalog No. ABIN4837784
Datasheet
Catalog No. ABIN4837784
Type:
cDNA
Application:
Cloning
Gene:
PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2)
NCBI Accession:
NM_000535
Species:
Human
Synonyms:
PMS2, Pms2, LOC463257, LOC107984056
Insert length:
2589 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Sequencing Primer:
  • GST Forward primer: 5'-CACGTTTGGTGGTGGCGAC3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human PMS2 cDNA Clone in Bacterial Expression Vector (His tag)
cDNA Clon Bacterial Expression Vector pPB-N-His Kanamycin T7 Promoter His tag Transient
Type:
cDNA
Application:
Cloning
Gene:
PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2)
NCBI Accession:
NM_000535
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Catalog No. ABIN4633263
Datasheet
Catalog No. ABIN4633263
Type:
cDNA
Application:
Cloning
Gene:
PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2)
NCBI Accession:
NM_000535
Species:
Human
Synonyms:
PMS2, Pms2, LOC463257, LOC107984056
Insert length:
2589 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Sequencing Primer:
  • T7 promoter primer: 5'-TAATACGACTCACTATAGGG-3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
  • Type
    • Plasmid
    • Primer
  • Supplier
    • antibodies-online
    • OriGene
    • GenScript
  • Reactivity
    • Human
    • Mouse
    • Rat
  • Application
    • Protein Expression (PExp)
    • Genome Editing with Engineered Nucleases (GEEN)
    • RNA Interference (RNAi)
    • Cloning (Clon)
  • Conjugate
    • Un-conjugated
    • GFP tag
    • His tag
    • Myc-DYKDDDDK Tag
    • HA tag
    • His-GST
    • His-MBP
    • RFP tag
    • DYKDDDDK Tag
  • Vector Backbone
    • pLenti-U6-sgRNA-PGK-Neo
    • pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
    • pCMV6-Entry
    • pGFP-C-shLenti
    • pGFP-V-RS
    • pORF
    • pPB-His-GST
    • pPB-His-MBP
    • pPB-N-His
    • pPM-C-HA
    • pPM-C-His
    • pRS
    • pCas-Guide
    • pLenti-C-Myc-DDK
    • pLenti-C-mGFP
    • pRFP-C-RS
    • pCMV6-AC-GFP
    • pCMV6-XL5
    • pcDNA3.1+C-(K)-DYK
  • Vector
    • Lentiviral Vector
    • Mammalian Expression Vector
    • Bacterial Expression Vector
    • Retroviral Vector
    • Cloning Vector
  • Insert
    • cDNA
    • ORF
    • shRNA
    • gRNA + Cas9
    • gRNA
  • Type of Oligonucleotide
    • siRNA Oligo
  • Bacterial Resistance
    • Kanamycin
    • Ampicillin
    • Chloramphenicol
    • Spectinomycin
  • Expression Type
    • Transient
    • Stable
  • Selectable Marker
    • Puromycin
    • Neomycin
  • Promoter
    • U6 Promoter
    • CMV Promoter
    • T7 Promoter
    • PGK Promoter
    • SFFV Promoter
    • Enhanced CMV Promoter
  • Format
    • Lyophilized
    • Liquid
    • Viral Particles

Synonyms and alternative names related to PMS2

  • PMS1 homolog 2, mismatch repair system component (PMS2)
  • PMS1 homolog 2, mismatch repair system component (Pms2)
  • PMS1 homolog2, mismatch repair system component (Pms2)
  • mismatch repair endonuclease PMS2 (LOC463257)
  • mismatch repair endonuclease PMS2 (LOC107984056)
  • AW555130
  • HNPCC4
  • PMS2CL
  • PMSL2
  • Pmsl2

Gene-IDs for different species

Protein level used designations for PMS2

  • DNA mismatch repair protein PMS2
  • H_DJ0042M02.9
  • PMS1 protein homolog 2
  • mismatch repair endonuclease PMS2
  • PMS2 postmeiotic segregation increased 2
Other products related to PMS2 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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