PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D, PPM1D)
Short Description: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008].
More information related to gene PPM1D.
More information related to gene PPM1D.
Products related to PPM1D Gene:
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66 results
OriGene rc209328
ORF
PExp
Mammalian Expression Vector
pCMV6-Entry
Kanamycin
CMV Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D)
- NCBI Accession:
- NM_003620,NP_003611
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-Entry
- Resistance Gene:
- Kanamycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN5461957
$835.56
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 8 to 11 Business Days
OriGene rc209328l1
ORF
PExp
Lentiviral Vector
pLenti-C-Myc-DDK
Chloramphenicol
CMV Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D)
- NCBI Accession:
- NM_003620,NP_003611
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-C-Myc-DDK
- Resistance Gene:
- Chloramphenicol
- Promoter:
- CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN5461961
$1,132.56
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 21 to 22 Business Days
OriGene rc209328l2
ORF
PExp
Lentiviral Vector
pLenti-C-mGFP
Chloramphenicol
CMV Promoter
GFP tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D)
- NCBI Accession:
- NM_003620,NP_003611
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-C-mGFP
- Resistance Gene:
- Chloramphenicol
- Promoter:
- CMV Promoter
- Fusion Tag:
- GFP tag
- Expression:
- Transient
Catalog No. ABIN5461959
$1,132.56
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 21 to 22 Business Days
OriGene rr215612
ORF
PExp
Mammalian Expression Vector
pCMV6-Entry
Kanamycin
CMV Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D)
- NCBI Accession:
- NM_001105825,NP_001099295
- Species:
- Rat
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-Entry
- Resistance Gene:
- Kanamycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN5461958
$605.88
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 31 to 32 Business Days
ORF
PExp
Mammalian Expression Vector
pcDNA3.1+C-(K)-DYK
Ampicillin
CMV Promoter
DYKDDDDK Tag
Transient
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D)
- NCBI Accession:
- NM_003620
- Gene ID:
- 8493 (Human, PPM1D)
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pcDNA3.1+C-(K)-DYK
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- DYKDDDDK Tag
- Expression:
- Transient, Stable
Catalog No. ABIN4936415
$379.00
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 4 to 7 Business Days
OriGene sr305566
RNAi
PPM1D
Species: Human
HPLC purified
- Application:
- RNA Interference
- Gene:
- Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D
- Species:
- Human
- Purification:
- HPLC purified
Catalog No. ABIN3345332
$512.82
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 4 to 9 Business Days
Synonyms and alternative names related to PPM1D
- protein phosphatase, Mg2+/Mn2+ dependent 1D (PPM1D)
- protein phosphatase 1D magnesium-dependent, delta isoform (Ppm1d)
- protein phosphatase, Mg2+/Mn2+ dependent, 1D (Ppm1d)
- protein phosphatase, Mg2+/Mn2+ dependent, 1Db (ppm1db)
- protein phosphatase, Mg2+/Mn2+ dependent 1D L homeolog (ppm1d.L)
- protein phosphatase, Mg2+/Mn2+ dependent, 1Da (ppm1da)
- AV338790
- PP2C-DELTA
- ppm1d
- WIP1
- Wip1
- wu:fj44c08
- zgc:55836
- zgc:77316
- zgc:103518
Gene-IDs for different species
Protein level used designations for PPM1D
- protein phosphatase 1D
- protein phosphatase 1D magnesium-dependent, delta isoform
- protein phosphatase 2C delta isoform
- protein phosphatase Wip1
- wild-type p53-induced phosphatase 1
- PP2C-delta
- p53-induced protein phosphatase 1
- protein phosphatase 2C isoform delta
- protein phosphatase magnesium-dependent 1 delta
- protein phosphatase 1D magnesium-dependent, delta
- protein phosphatase, Mg2+/Mn2+ dependent 1D L homeolog
- protein phosphatase, Mg2+/Mn2+ dependent, 1D
Proteomics products related to PPM1D Gene
Other products related to PPM1D such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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