PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D, PPM1D)
Short Description: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008].
More information related to gene PPM1D.
More information related to gene PPM1D.
Products related to PPM1D Gene:
Recommended next Filters:
66 results :
ORF
Clon
Cloning Vector
pORF
Spectinomycin
unconjugated
Transient
- Type:
- ORF
- Application:
- Cloning
- Gene:
- Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D)
- Species:
- Human
- Vector type:
- Cloning Vector
- Vector backbone:
- pORF
- Resistance Gene:
- Spectinomycin
- Expression:
- Transient
ORF
Clon
Cloning Vector
pORF
Spectinomycin
unconjugated
Transient
- Type:
- ORF
- Application:
- Cloning
- Gene:
- Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D)
- Species:
- Human
- Vector type:
- Cloning Vector
- Vector backbone:
- pORF
- Resistance Gene:
- Spectinomycin
- Expression:
- Transient
cDNA
PExp
Mammalian Expression Vector
pPM-C-HA
Kanamycin
CMV Promoter
HA tag
Stable
- Type:
- cDNA
- Application:
- Protein Expression
- Gene:
- Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D)
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pPM-C-HA
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- HA tag
- Expression:
- Stable, Transient
cDNA
PExp
Mammalian Expression Vector
pPM-C-HA
Kanamycin
CMV Promoter
HA tag
Stable
- Type:
- cDNA
- Application:
- Protein Expression
- Gene:
- Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D)
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pPM-C-HA
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- HA tag
- Expression:
- Stable, Transient
gRNA
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-PGK-Neo
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D)
- NCBI Accession:
- NM_001105825
- Species:
- Rat
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-PGK-Neo
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- U6 Promoter, PGK Promoter
- Expression:
- Stable, Transient
gRNA
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-PGK-Neo
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D)
- NCBI Accession:
- NM_016910
- Species:
- Mouse
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-PGK-Neo
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- U6 Promoter, PGK Promoter
- Expression:
- Stable, Transient
gRNA
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-PGK-Neo
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D)
- NCBI Accession:
- NM_003620
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-PGK-Neo
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- U6 Promoter, PGK Promoter
- Expression:
- Stable, Transient
cDNA
Clon
Bacterial Expression Vector
pPB-His-GST
Kanamycin
T7 Promoter
His-GST
Transient
- Type:
- cDNA
- Application:
- Cloning
- Gene:
- Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D)
- Species:
- Human
- Vector type:
- Bacterial Expression Vector
- Vector backbone:
- pPB-His-GST
- Resistance Gene:
- Kanamycin
- Promoter:
- T7 Promoter
- Fusion Tag:
- His-GST
- Expression:
- Transient
cDNA
Clon
Bacterial Expression Vector
pPB-His-GST
Kanamycin
T7 Promoter
His-GST
Transient
- Type:
- cDNA
- Application:
- Cloning
- Gene:
- Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D)
- Species:
- Human
- Vector type:
- Bacterial Expression Vector
- Vector backbone:
- pPB-His-GST
- Resistance Gene:
- Kanamycin
- Promoter:
- T7 Promoter
- Fusion Tag:
- His-GST
- Expression:
- Transient
cDNA
Clon
Bacterial Expression Vector
pPB-N-His
Kanamycin
T7 Promoter
His tag
Transient
- Type:
- cDNA
- Application:
- Cloning
- Gene:
- Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D)
- Species:
- Human
- Vector type:
- Bacterial Expression Vector
- Vector backbone:
- pPB-N-His
- Resistance Gene:
- Kanamycin
- Promoter:
- T7 Promoter
- Fusion Tag:
- His tag
- Expression:
- Transient
Synonyms and alternative names related to PPM1D
- protein phosphatase, Mg2+/Mn2+ dependent 1D (PPM1D)
- protein phosphatase 1D magnesium-dependent, delta isoform (Ppm1d)
- protein phosphatase, Mg2+/Mn2+ dependent, 1D (Ppm1d)
- protein phosphatase, Mg2+/Mn2+ dependent, 1Db (ppm1db)
- protein phosphatase, Mg2+/Mn2+ dependent 1D L homeolog (ppm1d.L)
- protein phosphatase, Mg2+/Mn2+ dependent, 1Da (ppm1da)
- AV338790
- PP2C-DELTA
- ppm1d
- WIP1
- Wip1
- wu:fj44c08
- zgc:55836
- zgc:77316
- zgc:103518
Gene-IDs for different species
Protein level used designations for PPM1D
- protein phosphatase 1D
- protein phosphatase 1D magnesium-dependent, delta isoform
- protein phosphatase 2C delta isoform
- protein phosphatase Wip1
- wild-type p53-induced phosphatase 1
- PP2C-delta
- p53-induced protein phosphatase 1
- protein phosphatase 2C isoform delta
- protein phosphatase magnesium-dependent 1 delta
- protein phosphatase 1D magnesium-dependent, delta
- protein phosphatase, Mg2+/Mn2+ dependent 1D L homeolog
- protein phosphatase, Mg2+/Mn2+ dependent, 1D
Proteomics products related to PPM1D Gene
Other products related to PPM1D such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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