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PPP1R12A (Myosin Phosphatase, Target Subunit 1, PPP1R12A)

Short Description: Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009].
More information related to gene PPP1R12A.

Products related to PPP1R12A Gene:

74 results :

Human PPP1R12A ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
Myosin Phosphatase, Target Subunit 1 (PPP1R12A)
Species:
Human
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5726592
Datasheet
Catalog No. ABIN5726592
Type:
ORF
Application:
Cloning
Gene:
Myosin Phosphatase, Target Subunit 1 (PPP1R12A)
Species:
Human
Synonyms:
Ppp1r12a, PPP1R12A
Insert length:
3093 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Rat PPP1R12A CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Myosin Phosphatase, Target Subunit 1 (PPP1R12A)
NCBI Accession:
NM_053890
Species:
Rat
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5092772
Datasheet
Catalog No. ABIN5092772
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Myosin Phosphatase, Target Subunit 1 (PPP1R12A)
NCBI Accession:
NM_053890
Species:
Rat
Synonyms:
Ppp1r12a, PPP1R12A
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Ppp1r12a
Format:
Viral Particles
Storage:
-80 °C
Mouse PPP1R12A CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Myosin Phosphatase, Target Subunit 1 (PPP1R12A)
NCBI Accession:
NM_027892
Species:
Mouse
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5092770
Datasheet
Catalog No. ABIN5092770
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Myosin Phosphatase, Target Subunit 1 (PPP1R12A)
NCBI Accession:
NM_027892
Species:
Mouse
Synonyms:
Ppp1r12a, PPP1R12A
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Ppp1r12a
Format:
Viral Particles
Storage:
-80 °C
Human PPP1R12A CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Myosin Phosphatase, Target Subunit 1 (PPP1R12A)
NCBI Accession:
NM_002480
Species:
Human
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5092768
Datasheet
Catalog No. ABIN5092768
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Myosin Phosphatase, Target Subunit 1 (PPP1R12A)
NCBI Accession:
NM_002480
Species:
Human
Synonyms:
Ppp1r12a, PPP1R12A
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of PPP1R12A
Format:
Viral Particles
Storage:
-80 °C
Mouse PPP1R12A ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
Myosin Phosphatase, Target Subunit 1 (PPP1R12A)
NCBI Accession:
NM_027892
Species:
Mouse
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5726593
Datasheet
Catalog No. ABIN5726593
Type:
ORF
Application:
Cloning
Gene:
Myosin Phosphatase, Target Subunit 1 (PPP1R12A)
NCBI Accession:
NM_027892
Species:
Mouse
Synonyms:
Ppp1r12a, PPP1R12A
Insert length:
3015 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Rat PPP1R12A ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
Myosin Phosphatase, Target Subunit 1 (PPP1R12A)
NCBI Accession:
NM_053890
Species:
Rat
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5726594
Datasheet
Catalog No. ABIN5726594
Type:
ORF
Application:
Cloning
Gene:
Myosin Phosphatase, Target Subunit 1 (PPP1R12A)
NCBI Accession:
NM_053890
Species:
Rat
Synonyms:
Ppp1r12a, PPP1R12A
Insert length:
2931 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Mouse PPP1R12A CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Myosin Phosphatase, Target Subunit 1 (PPP1R12A)
NCBI Accession:
NM_027892
Species:
Mouse
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5207958
Datasheet
Catalog No. ABIN5207958
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Myosin Phosphatase, Target Subunit 1 (PPP1R12A)
NCBI Accession:
NM_027892
Species:
Mouse
Synonyms:
Ppp1r12a, PPP1R12A
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Ppp1r12a
Format:
Viral Particles
Storage:
-80 °C
Human PPP1R12A CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Myosin Phosphatase, Target Subunit 1 (PPP1R12A)
NCBI Accession:
NM_002480
Species:
Human
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5207956
Datasheet
Catalog No. ABIN5207956
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Myosin Phosphatase, Target Subunit 1 (PPP1R12A)
NCBI Accession:
NM_002480
Species:
Human
Synonyms:
Ppp1r12a, PPP1R12A
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of PPP1R12A
Format:
Viral Particles
Storage:
-80 °C
Rat PPP1R12A CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Myosin Phosphatase, Target Subunit 1 (PPP1R12A)
NCBI Accession:
NM_053890
Species:
Rat
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5207960
Datasheet
Catalog No. ABIN5207960
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Myosin Phosphatase, Target Subunit 1 (PPP1R12A)
NCBI Accession:
NM_053890
Species:
Rat
Synonyms:
Ppp1r12a, PPP1R12A
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Ppp1r12a
Format:
Viral Particles
Storage:
-80 °C
Human PPP1R12A cDNA Clone in Mammalian Expression Vector (HA tag)
cDNA PExp Mammalian Expression Vector pPM-C-HA Kanamycin CMV Promoter HA tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
Myosin Phosphatase, Target Subunit 1 (PPP1R12A)
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Catalog No. ABIN4485704
Datasheet
Catalog No. ABIN4485704
Type:
cDNA
Application:
Protein Expression
Gene:
Myosin Phosphatase, Target Subunit 1 (PPP1R12A)
Species:
Human
Synonyms:
Ppp1r12a, PPP1R12A
Insert length:
3093 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
  • Type
    • Plasmid
    • Primer
  • Supplier
    • OriGene
    • antibodies-online
    • GenScript
    • ProteoGenix
  • Reactivity
    • Human
    • Rat
    • Mouse
  • Application
    • Protein Expression (PExp)
    • Genome Editing with Engineered Nucleases (GEEN)
    • Cloning (Clon)
    • RNA Interference (RNAi)
  • Conjugate
    • Un-conjugated
    • GFP tag
    • Myc-DYKDDDDK Tag
    • His tag
    • DYKDDDDK Tag
    • HA tag
    • His-GST
    • His-MBP
    • RFP tag
  • Vector Backbone
    • pCMV6-Entry
    • pLenti-U6-sgRNA-PGK-Neo
    • pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
    • pCMV6-AC-GFP
    • pLenti-C-Myc-DDK
    • pLenti-C-mGFP
    • pcDNA3.1+C-(K)-DYK
    • pGFP-C-shLenti
    • pGFP-V-RS
    • pORF
    • pPB-His-GST
    • pPB-His-MBP
    • pPB-N-His
    • pPM-C-HA
    • pPM-C-His
    • pRS
    • pCMV6-XL4
    • pCas-Guide
    • pDONR223
    • pRFP-C-RS
  • Vector
    • Mammalian Expression Vector
    • Lentiviral Vector
    • Bacterial Expression Vector
    • Retroviral Vector
    • Cloning Vector
    • Gateway Cloning Vector
  • Insert
    • ORF
    • cDNA
    • shRNA
    • gRNA + Cas9
    • gRNA
  • Type of Oligonucleotide
    • siRNA Oligo
  • Bacterial Resistance
    • Ampicillin
    • Kanamycin
    • Chloramphenicol
    • Spectinomycin
  • Expression Type
    • Transient
    • Stable
  • Selectable Marker
    • Neomycin
    • Puromycin
  • Promoter
    • CMV Promoter
    • U6 Promoter
    • T7 Promoter
    • Enhanced CMV Promoter
    • PGK Promoter
    • SFFV Promoter
  • Format
    • Lyophilized
    • Liquid
    • Viral Particles

Synonyms and alternative names related to PPP1R12A

  • protein phosphatase 1, regulatory (inhibitor) subunit 12A (Ppp1r12a)
  • protein phosphatase 1 regulatory subunit 12A (PPP1R12A)
  • protein phosphatase 1, regulatory subunit 12A (Ppp1r12a)
  • 1200015F06Rik
  • 5730577I22Rik
  • AA792106
  • AV099298
  • D10Ertd625e
  • M110
  • M130
  • MBS
  • MBSP
  • Mypt1
  • MYPT1

Gene-IDs for different species

Protein level used designations for PPP1R12A

  • myosin phosphatase target subunit 1
  • myosin phosphatase, target subunit 1
  • myosin phosphatase-targeting subunit 1
  • protein phosphatase 1 regulatory subunit 12A
  • myosin binding subunit
  • protein phosphatase 1, regulatory (inhibitor) subunit 12A
  • protein phosphatase myosin-binding subunit
  • PP-1M
  • protein phosphatase subunit 1M
  • serine/threonine protein phosphatase PP1 smooth muscle regulatory subunit M110
  • smooth muscle myosin phosphatase myosin-binding subunit
  • 130 kDa myosin-binding subunit of smooth muscle myosin phophatase
  • 130 kDa myosin-binding subunit of smooth muscle myosin phosphatase
  • 133kDa myosin-binding subunit of smooth muscle myosin phosphatase (M133)
  • PP1M subunit M110
Other products related to PPP1R12A such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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