Topoisomerase II alpha (Topoisomerase (DNA) II alpha 170kDa, TOP2A)
Short Description: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010].
More information related to gene Topoisomerase II alpha.
More information related to gene Topoisomerase II alpha.
Products related to Topoisomerase II alpha Gene:
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52 results
OriGene kn518059
gRNA + Cas9
GEEN
Mammalian Expression Vector
pCas-Guide
Ampicillin
U6 Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- gRNA + Cas9
- Application:
- Genome Editing with Engineered Nucleases
- Gene:
- Topoisomerase (DNA) II alpha 170kDa (TOP2A)
- Species:
- Mouse
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCas-Guide
- Resistance Gene:
- Ampicillin
- Promoter:
- U6 Promoter, Enhanced CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN3258342
$1,640.43
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 21 to 22 Business Days
OriGene kn421568
gRNA + Cas9
GEEN
Mammalian Expression Vector
pCas-Guide
Ampicillin
U6 Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- gRNA + Cas9
- Application:
- Genome Editing with Engineered Nucleases
- Gene:
- Topoisomerase (DNA) II alpha 170kDa (TOP2A)
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCas-Guide
- Resistance Gene:
- Ampicillin
- Promoter:
- U6 Promoter, Enhanced CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN3258341
$1,640.43
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 21 to 22 Business Days
OriGene sr422969
RNAi
TOP2A
Species: Mouse
HPLC purified
- Application:
- RNA Interference
- Gene:
- Topoisomerase (DNA) II alpha 170kDa
- Species:
- Mouse
- Purification:
- HPLC purified
Catalog No. ABIN3349819
$512.82
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
OriGene sr508693
RNAi
TOP2A
Species: Rat
HPLC purified
- Application:
- RNA Interference
- Gene:
- Topoisomerase (DNA) II alpha 170kDa
- Species:
- Rat
- Purification:
- HPLC purified
Catalog No. ABIN3358003
$512.82
Plus shipping costs $50.00
1 kit
Shipping to:
United States
Delivery in 16 to 17 Business Days
OriGene sc127832
cDNA
PExp
Mammalian Expression Vector
pCMV6-Entry
Kanamycin
Enhanced CMV Promoter
unconjugated
Transient
1
- Type:
- cDNA
- Application:
- Protein Expression
- Gene:
- Topoisomerase (DNA) II alpha 170kDa (TOP2A)
- NCBI Accession:
- NM_001067,NP_001058
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-Entry
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Neomycin
- Promoter:
- Enhanced CMV Promoter
- Expression:
- Transient
Catalog No. ABIN3307431
$1,945.35
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 4 to 9 Business Days
OriGene rn208980
cDNA
PExp
Mammalian Expression Vector
pCMV6-Entry
Kanamycin
Enhanced CMV Promoter
unconjugated
Transient
1
- Type:
- cDNA
- Application:
- Protein Expression
- Gene:
- Topoisomerase (DNA) II alpha 170kDa (TOP2A)
- NCBI Accession:
- NM_022183,NP_071519
- Species:
- Rat
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-Entry
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Neomycin
- Promoter:
- Enhanced CMV Promoter
- Expression:
- Transient
Catalog No. ABIN3337340
$1,422.63
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 41 to 42 Business Days
OriGene mc224642
cDNA
PExp
Mammalian Expression Vector
pCMV6-Entry
Kanamycin
Enhanced CMV Promoter
unconjugated
Transient
1
- Type:
- cDNA
- Application:
- Protein Expression
- Gene:
- Topoisomerase (DNA) II alpha 170kDa (TOP2A)
- NCBI Accession:
- NM_011623,NP_035753
- Species:
- Mouse
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-Entry
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Neomycin
- Promoter:
- Enhanced CMV Promoter
- Expression:
- Transient
Catalog No. ABIN3337339
$1,424.61
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 41 to 42 Business Days
ORF
PExp
Mammalian Expression Vector
pcDNA3.1+C-(K)-DYK
Ampicillin
CMV Promoter
DYKDDDDK Tag
Transient
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Topoisomerase (DNA) II alpha 170kDa (TOP2A)
- NCBI Accession:
- NM_001067
- Gene ID:
- 7153 (Human, TOP2A)
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pcDNA3.1+C-(K)-DYK
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- DYKDDDDK Tag
- Expression:
- Transient, Stable
Catalog No. ABIN4946494
$549.00
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 26 to 27 Business Days
OriGene rg221568
ORF
PExp
Mammalian Expression Vector
pCMV6-AC-GFP
Ampicillin
CMV Promoter
GFP tag
Stable
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Topoisomerase (DNA) II alpha 170kDa (TOP2A)
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-AC-GFP
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- GFP tag
- Expression:
- Stable, Transient
Catalog No. ABIN5449712
$2,142.36
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 8 to 11 Business Days
OriGene rc221568
ORF
PExp
Mammalian Expression Vector
pCMV6-Entry
Kanamycin
CMV Promoter
Myc-DYKDDDDK Tag
Transient
1
- Type:
- ORF
- Application:
- Protein Expression
- Gene:
- Topoisomerase (DNA) II alpha 170kDa (TOP2A)
- NCBI Accession:
- NM_001067,NP_001058
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pCMV6-Entry
- Resistance Gene:
- Kanamycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- Myc-DYKDDDDK Tag
- Expression:
- Transient
Catalog No. ABIN5449713
$1,944.36
Plus shipping costs $50.00
10 μg
Shipping to:
United States
Delivery in 8 to 11 Business Days
Synonyms and alternative names related to Topoisomerase II alpha
- DNA topoisomerase II alpha (TOP2A)
- DNA topoisomerase II, alpha isozyme (Bm1_08705)
- topoisomerase (DNA) II alpha (Top2a)
- DNA topoisomerase II alpha (Top2a)
- topoisomerase (DNA) II alpha (TOP2A)
- Zincin-like metalloproteases family protein (AT5G10540)
- DNA topoisomerase II alpha (top2a)
- F12B17.110
- F12B17_110
- fc08c07
- thimet metalloendopeptidase 2
- Top-2
- TOP-2
- TOP2
- TOP2A
- TP2A
- wu:fc08c07
Gene-IDs for different species
Protein level used designations for Topoisomerase II alpha
- DNA gyrase
- DNA topoisomerase (ATP-hydrolyzing)
- DNA topoisomerase 2-alpha
- DNA topoisomerase II, 170 kD
- DNA topoisomerase II, alpha isozyme
- DNA Topoisomerase II alpha
- topoisomerase (DNA) 2 alpha
- DNA topoisomeraseII_alpha
- topoisomerase (DNA) II alpha
- Thimet metalloendopeptidase 2
- Zincin-like metalloproteases family protein 2
- topoisomerase 2
Proteomics products related to Topoisomerase II alpha Gene
Other products related to Topoisomerase II alpha such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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