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Topoisomerase II alpha (Topoisomerase (DNA) II alpha 170kDa, TOP2A)

Short Description: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010].
More information related to gene Topoisomerase II alpha.

Products related to Topoisomerase II alpha Gene:

53 results :

Rat TOP2A CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Topoisomerase (DNA) II alpha 170kDa (TOP2A)
NCBI Accession:
NM_022183
Species:
Rat
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5263135
Datasheet
Catalog No. ABIN5263135
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Topoisomerase (DNA) II alpha 170kDa (TOP2A)
NCBI Accession:
NM_022183
Species:
Rat
Synonyms:
TOP2A, Bm1_08705, Top2a, AT5G10540, top2a
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Top2a
Format:
Viral Particles
Storage:
-80 °C
Mouse TOP2A CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Topoisomerase (DNA) II alpha 170kDa (TOP2A)
NCBI Accession:
NM_011623
Species:
Mouse
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5263133
Datasheet
Catalog No. ABIN5263133
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Topoisomerase (DNA) II alpha 170kDa (TOP2A)
NCBI Accession:
NM_011623
Species:
Mouse
Synonyms:
TOP2A, Bm1_08705, Top2a, AT5G10540, top2a
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Top2a
Format:
Viral Particles
Storage:
-80 °C
Human TOP2A CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Topoisomerase (DNA) II alpha 170kDa (TOP2A)
NCBI Accession:
NM_001067
Species:
Human
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5263131
Datasheet
Catalog No. ABIN5263131
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Topoisomerase (DNA) II alpha 170kDa (TOP2A)
NCBI Accession:
NM_001067
Species:
Human
Synonyms:
TOP2A, Bm1_08705, Top2a, AT5G10540, top2a
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of TOP2A
Format:
Viral Particles
Storage:
-80 °C
Human TOP2A cDNA Clone in Mammalian Expression Vector (HA tag)
cDNA PExp Mammalian Expression Vector pPM-C-HA Kanamycin CMV Promoter HA tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
Topoisomerase (DNA) II alpha 170kDa (TOP2A)
NCBI Accession:
NM_001067
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Catalog No. ABIN4490786
Datasheet
Catalog No. ABIN4490786
Type:
cDNA
Application:
Protein Expression
Gene:
Topoisomerase (DNA) II alpha 170kDa (TOP2A)
NCBI Accession:
NM_001067
Species:
Human
Synonyms:
TOP2A, Bm1_08705, Top2a, AT5G10540, top2a
Insert length:
4596 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Rat TOP2A CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Topoisomerase (DNA) II alpha 170kDa (TOP2A)
NCBI Accession:
NM_022183
Species:
Rat
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5147604
Datasheet
Catalog No. ABIN5147604
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Topoisomerase (DNA) II alpha 170kDa (TOP2A)
NCBI Accession:
NM_022183
Species:
Rat
Synonyms:
TOP2A, Bm1_08705, Top2a, AT5G10540, top2a
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Top2a
Format:
Viral Particles
Storage:
-80 °C
Mouse TOP2A CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Topoisomerase (DNA) II alpha 170kDa (TOP2A)
NCBI Accession:
NM_011623
Species:
Mouse
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5147602
Datasheet
Catalog No. ABIN5147602
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Topoisomerase (DNA) II alpha 170kDa (TOP2A)
NCBI Accession:
NM_011623
Species:
Mouse
Synonyms:
TOP2A, Bm1_08705, Top2a, AT5G10540, top2a
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Top2a
Format:
Viral Particles
Storage:
-80 °C
Human TOP2A CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Topoisomerase (DNA) II alpha 170kDa (TOP2A)
NCBI Accession:
NM_001067
Species:
Human
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5147600
Datasheet
Catalog No. ABIN5147600
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Topoisomerase (DNA) II alpha 170kDa (TOP2A)
NCBI Accession:
NM_001067
Species:
Human
Synonyms:
TOP2A, Bm1_08705, Top2a, AT5G10540, top2a
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of TOP2A
Format:
Viral Particles
Storage:
-80 °C
Human TOP2A cDNA Clone in Bacterial Expression Vector (His-GST)
cDNA Clon Bacterial Expression Vector pPB-His-GST Kanamycin T7 Promoter His-GST Transient
Type:
cDNA
Application:
Cloning
Gene:
Topoisomerase (DNA) II alpha 170kDa (TOP2A)
NCBI Accession:
NM_001067
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Catalog No. ABIN4842200
Datasheet
Catalog No. ABIN4842200
Type:
cDNA
Application:
Cloning
Gene:
Topoisomerase (DNA) II alpha 170kDa (TOP2A)
NCBI Accession:
NM_001067
Species:
Human
Synonyms:
TOP2A, Bm1_08705, Top2a, AT5G10540, top2a
Insert length:
4596 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Sequencing Primer:
  • GST Forward primer: 5'-CACGTTTGGTGGTGGCGAC3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human TOP2A cDNA Clone in Bacterial Expression Vector (His tag)
cDNA Clon Bacterial Expression Vector pPB-N-His Kanamycin T7 Promoter His tag Transient
Type:
cDNA
Application:
Cloning
Gene:
Topoisomerase (DNA) II alpha 170kDa (TOP2A)
NCBI Accession:
NM_001067
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Catalog No. ABIN4634255
Datasheet
Catalog No. ABIN4634255
Type:
cDNA
Application:
Cloning
Gene:
Topoisomerase (DNA) II alpha 170kDa (TOP2A)
NCBI Accession:
NM_001067
Species:
Human
Synonyms:
TOP2A, Bm1_08705, Top2a, AT5G10540, top2a
Insert length:
4596 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Sequencing Primer:
  • T7 promoter primer: 5'-TAATACGACTCACTATAGGG-3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human TOP2A cDNA Clone in Bacterial Expression Vector (His-MBP)
cDNA Clon Bacterial Expression Vector pPB-His-MBP Kanamycin T7 Promoter His-MBP Transient
Type:
cDNA
Application:
Cloning
Gene:
Topoisomerase (DNA) II alpha 170kDa (TOP2A)
NCBI Accession:
NM_001067
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-MBP
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-MBP
Expression:
Transient
Catalog No. ABIN4713069
Datasheet
Catalog No. ABIN4713069
Type:
cDNA
Application:
Cloning
Gene:
Topoisomerase (DNA) II alpha 170kDa (TOP2A)
NCBI Accession:
NM_001067
Species:
Human
Synonyms:
TOP2A, Bm1_08705, Top2a, AT5G10540, top2a
Insert length:
4596 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-MBP
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-MBP
Expression:
Transient
Sequencing Primer:
  • MBP Forward primer: 5'-CGCAGATGTCCGCTTTCTGG-3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
  • Type
    • Plasmid
    • Primer
  • Supplier
    • antibodies-online
    • OriGene
    • GenScript
  • Reactivity
    • Human
    • Mouse
    • Rat
  • Application
    • Protein Expression (PExp)
    • Genome Editing with Engineered Nucleases (GEEN)
    • RNA Interference (RNAi)
    • Cloning (Clon)
  • Conjugate
    • Un-conjugated
    • GFP tag
    • His tag
    • Myc-DYKDDDDK Tag
    • HA tag
    • His-GST
    • His-MBP
    • RFP tag
    • DYKDDDDK Tag
  • Vector Backbone
    • pLenti-U6-sgRNA-PGK-Neo
    • pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
    • pCMV6-Entry
    • pGFP-C-shLenti
    • pGFP-V-RS
    • pORF
    • pPB-His-GST
    • pPB-His-MBP
    • pPB-N-His
    • pPM-C-HA
    • pPM-C-His
    • pRS
    • pCas-Guide
    • pRFP-C-RS
    • pCMV6-AC-GFP
    • pLenti-C-Myc-DDK
    • pLenti-C-mGFP
    • pcDNA3.1+C-(K)-DYK
  • Vector
    • Lentiviral Vector
    • Mammalian Expression Vector
    • Bacterial Expression Vector
    • Retroviral Vector
    • Cloning Vector
  • Insert
    • cDNA
    • shRNA
    • ORF
    • gRNA + Cas9
    • gRNA
  • Type of Oligonucleotide
    • siRNA Oligo
  • Bacterial Resistance
    • Kanamycin
    • Ampicillin
    • Chloramphenicol
    • Spectinomycin
  • Expression Type
    • Transient
    • Stable
  • Selectable Marker
    • Neomycin
    • Puromycin
  • Promoter
    • U6 Promoter
    • CMV Promoter
    • T7 Promoter
    • PGK Promoter
    • SFFV Promoter
    • Enhanced CMV Promoter
  • Format
    • Lyophilized
    • Liquid
    • Viral Particles

Synonyms and alternative names related to Topoisomerase II alpha

  • DNA topoisomerase II alpha (TOP2A)
  • DNA topoisomerase II, alpha isozyme (Bm1_08705)
  • topoisomerase (DNA) II alpha (Top2a)
  • DNA topoisomerase II alpha (Top2a)
  • topoisomerase (DNA) II alpha (TOP2A)
  • Zincin-like metalloproteases family protein (AT5G10540)
  • DNA topoisomerase II alpha (top2a)
  • F12B17.110
  • F12B17_110
  • fc08c07
  • thimet metalloendopeptidase 2
  • Top-2
  • TOP-2
  • TOP2
  • TOP2A
  • TP2A
  • wu:fc08c07

Gene-IDs for different species

Protein level used designations for Topoisomerase II alpha

  • DNA gyrase
  • DNA topoisomerase (ATP-hydrolyzing)
  • DNA topoisomerase 2-alpha
  • DNA topoisomerase II, 170 kD
  • DNA topoisomerase II, alpha isozyme
  • DNA Topoisomerase II alpha
  • topoisomerase (DNA) 2 alpha
  • DNA topoisomeraseII_alpha
  • topoisomerase (DNA) II alpha
  • Thimet metalloendopeptidase 2
  • Zincin-like metalloproteases family protein 2
  • topoisomerase 2
Other products related to Topoisomerase II alpha such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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