HSD11B2 (Hydroxysteroid (11-Beta) Dehydrogenase 2, HSD11B2)
Short Description: There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010].
More information related to gene HSD11B2.
More information related to gene HSD11B2.
Products related to HSD11B2 Gene:
Recommended next Filters:
56 results :
ORF
Clon
Cloning Vector
pORF
Spectinomycin
unconjugated
Transient
- Type:
- ORF
- Application:
- Cloning
- Gene:
- Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2)
- NCBI Accession:
- NM_000196
- Species:
- Human
- Vector type:
- Cloning Vector
- Vector backbone:
- pORF
- Resistance Gene:
- Spectinomycin
- Expression:
- Transient
gRNA
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-PGK-Neo
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2)
- NCBI Accession:
- NM_017081
- Species:
- Rat
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-PGK-Neo
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- U6 Promoter, PGK Promoter
- Expression:
- Stable, Transient
gRNA
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-PGK-Neo
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2)
- NCBI Accession:
- NM_000196
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-PGK-Neo
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- U6 Promoter, PGK Promoter
- Expression:
- Stable, Transient
gRNA
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-PGK-Neo
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2)
- NCBI Accession:
- NM_008289
- Species:
- Mouse
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-PGK-Neo
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- U6 Promoter, PGK Promoter
- Expression:
- Stable, Transient
ORF
Clon
Cloning Vector
pORF
Spectinomycin
unconjugated
Transient
- Type:
- ORF
- Application:
- Cloning
- Gene:
- Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2)
- NCBI Accession:
- NM_008289
- Species:
- Mouse
- Vector type:
- Cloning Vector
- Vector backbone:
- pORF
- Resistance Gene:
- Spectinomycin
- Expression:
- Transient
ORF
Clon
Cloning Vector
pORF
Spectinomycin
unconjugated
Transient
- Type:
- ORF
- Application:
- Cloning
- Gene:
- Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2)
- NCBI Accession:
- NM_017081
- Species:
- Rat
- Vector type:
- Cloning Vector
- Vector backbone:
- pORF
- Resistance Gene:
- Spectinomycin
- Expression:
- Transient
gRNA + Cas9
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA + Cas9
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2)
- NCBI Accession:
- NM_017081
- Species:
- Rat
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter, SFFV Promoter
- Expression:
- Stable, Transient
gRNA + Cas9
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA + Cas9
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2)
- NCBI Accession:
- NM_008289
- Species:
- Mouse
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter, SFFV Promoter
- Expression:
- Stable, Transient
gRNA + Cas9
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA + Cas9
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2)
- NCBI Accession:
- NM_000196
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter, SFFV Promoter
- Expression:
- Stable, Transient
cDNA
PExp
Mammalian Expression Vector
pPM-C-HA
Kanamycin
CMV Promoter
HA tag
Stable
- Type:
- cDNA
- Application:
- Protein Expression
- Gene:
- Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2)
- NCBI Accession:
- NM_000196
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pPM-C-HA
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- HA tag
- Expression:
- Stable, Transient
Synonyms and alternative names related to HSD11B2
- hydroxysteroid (11-beta) dehydrogenase 2 L homeolog (hsd11b2.L)
- hydroxysteroid 11-beta dehydrogenase 2 (HSD11B2)
- hydroxysteroid 11-beta dehydrogenase 2 (Hsd11b2)
- 11-HSD2
- 11HSD2
- AME
- AME1
- HSD2
- HSD11B2
- HSD11K
- MGC81883
- SDR9C3
Gene-IDs for different species
Protein level used designations for HSD11B2
- hydroxysteroid (11-beta) dehydrogenase 2
- corticosteroid 11-beta-dehydrogenase isozyme 2
- 11 beta-hydroxysteroid dehydrogenase type 2
- -HSD11 type II
- 11-DH2
- 11-beta-HSD2
- 11-beta-hydroxysteroid dehydrogenase type 2
- 11-beta-hydroxysteroid dehydrogenase type II
- NAD-dependent 11-beta-hydroxysteroid dehydrogenase
- short chain dehydrogenase/reductase family 9C member 3
- 11-beta hydroxysteroid dehydrogenase
- hydroxysteroid 11-beta dehydrogenase 2
- 11-beta-hydroxysteroid dehydrogenase 2
- 11(beta)-HSD2
- Hydroxysteroid dehydrogenase, 11 beta type 2
Proteomics products related to HSD11B2 Gene
Other products related to HSD11B2 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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