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MDM2 (Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse), MDM2)

Short Description: This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq, Jul 2008].
More information related to gene MDM2.

Products related to MDM2 Gene:

72 results :

Human MDM2 ORF Clone in Cloning Vector
ORF Clon Cloning Vector pORF Spectinomycin unconjugated Transient
Type:
ORF
Application:
Cloning
Gene:
Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2)
NCBI Accession:
NM_002392
Species:
Human
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Catalog No. ABIN5763551
Datasheet
Catalog No. ABIN5763551
Type:
ORF
Application:
Cloning
Gene:
Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2)
NCBI Accession:
NM_002392
Species:
Human
Synonyms:
MDM2, mdm2.S, Mdm2, mdm2
Insert length:
1494 bp
Vector type:
Cloning Vector
Vector backbone:
pORF
Resistance Gene:
Spectinomycin
Expression:
Transient
Sequencing Primer:
  • M13 FP: 5'-CCCAGTCACGACGTTGTAAAACG-3'
    M13 RP: 5'-CAGGAAACAGCTATGAC-3'
Format:
Liquid
Buffer:
10  mM Tris-HCI, 1  mM EDTA,  pH 8.0
Storage:
-20 °C
Human MDM2 cDNA Clone in Mammalian Expression Vector (HA tag)
cDNA PExp Mammalian Expression Vector pPM-C-HA Kanamycin CMV Promoter HA tag Stable
Type:
cDNA
Application:
Protein Expression
Gene:
Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2)
NCBI Accession:
NM_002392
Species:
Human
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Catalog No. ABIN4488988
Datasheet
Catalog No. ABIN4488988
Type:
cDNA
Application:
Protein Expression
Gene:
Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2)
NCBI Accession:
NM_002392
Species:
Human
Synonyms:
MDM2, mdm2.S, Mdm2, mdm2
Insert length:
1494 bp
Vector type:
Mammalian Expression Vector
Vector backbone:
pPM-C-HA
Resistance Gene:
Kanamycin
Selection Marker:
Neomycin
Promoter:
CMV Promoter
Fusion Tag:
HA tag
Expression:
Stable, Transient
Sequencing Primer:
  • CMV sequencing primer: 5` CGC AAA TGG GCG GTA GGC GTG 3`
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Rat MDM2 CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2)
NCBI Accession:
NM_001108099
Species:
Rat
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5279049
Datasheet
Catalog No. ABIN5279049
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2)
NCBI Accession:
NM_001108099
Species:
Rat
Synonyms:
MDM2, mdm2.S, Mdm2, mdm2
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Mdm2
Format:
Viral Particles
Storage:
-80 °C
Mouse MDM2 CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2)
NCBI Accession:
NM_010786
Species:
Mouse
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5279047
Datasheet
Catalog No. ABIN5279047
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2)
NCBI Accession:
NM_010786
Species:
Mouse
Synonyms:
MDM2, mdm2.S, Mdm2, mdm2
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Mdm2
Format:
Viral Particles
Storage:
-80 °C
Human MDM2 CRISPR gRNA + Cas9 in Lenti Particles
gRNA + Cas9 PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2)
NCBI Accession:
NM_002392
Species:
Human
Vector type:
Lentiviral Vector
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Catalog No. ABIN5279045
Datasheet
Catalog No. ABIN5279045
Type:
gRNA + Cas9
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2)
NCBI Accession:
NM_002392
Species:
Human
Synonyms:
MDM2, mdm2.S, Mdm2, mdm2
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Resistance Gene:
Ampicillin
Selection Marker:
Puromycin
Promoter:
U6 Promoter, SFFV Promoter
Expression:
Stable, Transient
Sequencing Primer:
  • U6 Forward Primer: 5'--TACGTCCAAGGTCGGGCAGGAAGA--3'
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of MDM2
Format:
Viral Particles
Storage:
-80 °C
Rat MDM2 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2)
NCBI Accession:
NM_001108099
Species:
Rat
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5163464
Datasheet
Catalog No. ABIN5163464
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2)
NCBI Accession:
NM_001108099
Species:
Rat
Synonyms:
MDM2, mdm2.S, Mdm2, mdm2
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Mdm2
Format:
Viral Particles
Storage:
-80 °C
Mouse MDM2 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2)
NCBI Accession:
NM_010786
Species:
Mouse
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5163462
Datasheet
Catalog No. ABIN5163462
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2)
NCBI Accession:
NM_010786
Species:
Mouse
Synonyms:
MDM2, mdm2.S, Mdm2, mdm2
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of Mdm2
Format:
Viral Particles
Storage:
-80 °C
Human MDM2 CRISPR gRNA in Lenti Particles
gRNA PExp, GEEN Lentiviral Vector pLenti-U6-sgRNA-PGK-Neo Ampicillin U6 Promoter unconjugated Stable
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2)
NCBI Accession:
NM_002392
Species:
Human
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Catalog No. ABIN5163460
Datasheet
Catalog No. ABIN5163460
Type:
gRNA
Application:
Protein Expression, Genome Editing with Engineered Nucleases
Gene:
Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2)
NCBI Accession:
NM_002392
Species:
Human
Synonyms:
MDM2, mdm2.S, Mdm2, mdm2
Vector type:
Lentiviral Vector
Vector backbone:
pLenti-U6-sgRNA-PGK-Neo
Resistance Gene:
Ampicillin
Selection Marker:
Neomycin
Promoter:
U6 Promoter, PGK Promoter
Expression:
Stable, Transient
Components:
Lentiviral particles with an individual gRNA (300 μL) for a specific sequence of MDM2
Format:
Viral Particles
Storage:
-80 °C
Human MDM2 cDNA Clone in Bacterial Expression Vector (His-GST)
cDNA Clon Bacterial Expression Vector pPB-His-GST Kanamycin T7 Promoter His-GST Transient
Type:
cDNA
Application:
Cloning
Gene:
Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2)
NCBI Accession:
NM_002392
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Catalog No. ABIN4835143
Datasheet
Catalog No. ABIN4835143
Type:
cDNA
Application:
Cloning
Gene:
Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2)
NCBI Accession:
NM_002392
Species:
Human
Synonyms:
MDM2, mdm2.S, Mdm2, mdm2
Insert length:
1494 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-His-GST
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His-GST
Expression:
Transient
Sequencing Primer:
  • GST Forward primer: 5'-CACGTTTGGTGGTGGCGAC3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
Human MDM2 cDNA Clone in Bacterial Expression Vector (His tag)
cDNA Clon Bacterial Expression Vector pPB-N-His Kanamycin T7 Promoter His tag Transient
Type:
cDNA
Application:
Cloning
Gene:
Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2)
NCBI Accession:
NM_002392
Species:
Human
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Catalog No. ABIN4632457
Datasheet
Catalog No. ABIN4632457
Type:
cDNA
Application:
Cloning
Gene:
Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2)
NCBI Accession:
NM_002392
Species:
Human
Synonyms:
MDM2, mdm2.S, Mdm2, mdm2
Insert length:
1494 bp
Vector type:
Bacterial Expression Vector
Vector backbone:
pPB-N-His
Resistance Gene:
Kanamycin
Promoter:
T7 Promoter
Fusion Tag:
His tag
Expression:
Transient
Sequencing Primer:
  • T7 promoter primer: 5'-TAATACGACTCACTATAGGG-3'
  • T7 terminator primer: 5'-GCTAGTTATTGCTCAGCGG-3'
Format:
Liquid
Buffer:
10 mM Tris-HCI, 1 mM EDTA, pH 8.0
Storage:
-20 °C
  • Type
    • Plasmid
    • Primer
  • Supplier
    • OriGene
    • antibodies-online
    • GenScript
  • Reactivity
    • Human
    • Mouse
    • Rat
  • Cited in publications
  • Application
    • Protein Expression (PExp)
    • Genome Editing with Engineered Nucleases (GEEN)
    • RNA Interference (RNAi)
    • Cloning (Clon)
  • Conjugate
    • Un-conjugated
    • GFP tag
    • Myc-DYKDDDDK Tag
    • His tag
    • DYKDDDDK Tag
    • HA tag
    • His-GST
    • His-MBP
    • RFP tag
  • Vector Backbone
    • pCMV6-Entry
    • pLenti-U6-sgRNA-PGK-Neo
    • pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
    • pCMV6-AC-GFP
    • pcDNA3.1+C-(K)-DYK
    • pGFP-C-shLenti
    • pGFP-V-RS
    • pLenti-C-Myc-DDK
    • pLenti-C-mGFP
    • pORF
    • pPB-His-GST
    • pPB-His-MBP
    • pPB-N-His
    • pPM-C-HA
    • pPM-C-His
    • pRS
    • pCas-Guide
    • pRFP-C-RS
    • pCMV6-XL4
  • Vector
    • Mammalian Expression Vector
    • Lentiviral Vector
    • Bacterial Expression Vector
    • Retroviral Vector
    • Cloning Vector
  • Insert
    • ORF
    • cDNA
    • shRNA
    • gRNA + Cas9
    • gRNA
  • Type of Oligonucleotide
    • siRNA Oligo
  • Bacterial Resistance
    • Ampicillin
    • Kanamycin
    • Chloramphenicol
    • Spectinomycin
  • Expression Type
    • Transient
    • Stable
  • Selectable Marker
    • Neomycin
    • Puromycin
  • Promoter
    • CMV Promoter
    • U6 Promoter
    • T7 Promoter
    • Enhanced CMV Promoter
    • PGK Promoter
    • SFFV Promoter
  • Format
    • Lyophilized
    • Liquid
    • Viral Particles

Synonyms and alternative names related to MDM2

  • MDM2 proto-oncogene (MDM2)
  • MDM2 proto-oncogene S homeolog (mdm2.S)
  • MDM2 proto-oncogene (Mdm2)
  • Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) (MDM2)
  • MDM2 oncogene, E3 ubiquitin protein ligase (mdm2)
  • transformed mouse 3T3 cell double minute 2 (Mdm2)
  • 1700007J15Rik
  • AA415488
  • ACTFS
  • hdm2
  • HDMX
  • Mdm-2
  • zgc:109834

Gene-IDs for different species

Protein level used designations for MDM2

  • E3 ubiquitin-protein ligase Mdm2
  • Mdm2, p53 E3 ubiquitin protein ligase homolog
  • Mdm2, transformed 3T3 cell double minute 2, p53 binding protein
  • double minute 2, human homolog of; p53-binding protein
  • oncoprotein Mdm2
  • Mdm2 p53 binding protein homolog
  • double minute 2 protein
  • p53-binding protein Mdm2
  • xdm2
  • MDM2 alpha
  • cdm2
  • double minute 2 homolog
  • double minute 2
  • MDM2-like protein
  • edm2
  • transformed mouse 3T3 cell double minute 2
  • etID309863.4
  • murine double minute 2 homolog
Other products related to MDM2 such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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