PIP5K1A (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha, PIP5K1A)
Short Description: Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs.
More information related to gene PIP5K1A.
More information related to gene PIP5K1A.
Products related to PIP5K1A Gene:
Recommended next Filters:
73 results :
ORF
Clon
Cloning Vector
pORF
Spectinomycin
unconjugated
Transient
- Type:
- ORF
- Application:
- Cloning
- Gene:
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
- Species:
- Human
- Vector type:
- Cloning Vector
- Vector backbone:
- pORF
- Resistance Gene:
- Spectinomycin
- Expression:
- Transient
cDNA
PExp
Mammalian Expression Vector
pPM-C-HA
Kanamycin
CMV Promoter
HA tag
Stable
- Type:
- cDNA
- Application:
- Protein Expression
- Gene:
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
- Species:
- Human
- Vector type:
- Mammalian Expression Vector
- Vector backbone:
- pPM-C-HA
- Resistance Gene:
- Kanamycin
- Selection Marker:
- Neomycin
- Promoter:
- CMV Promoter
- Fusion Tag:
- HA tag
- Expression:
- Stable, Transient
gRNA + Cas9
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA + Cas9
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
- NCBI Accession:
- NM_001042621
- Species:
- Rat
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter, SFFV Promoter
- Expression:
- Stable, Transient
gRNA + Cas9
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA + Cas9
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
- NCBI Accession:
- NM_008847
- Species:
- Mouse
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter, SFFV Promoter
- Expression:
- Stable, Transient
gRNA + Cas9
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA + Cas9
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
- NCBI Accession:
- NM_001135636
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Puromycin
- Promoter:
- U6 Promoter, SFFV Promoter
- Expression:
- Stable, Transient
gRNA
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-PGK-Neo
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
- NCBI Accession:
- NM_001042621
- Species:
- Rat
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-PGK-Neo
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- U6 Promoter, PGK Promoter
- Expression:
- Stable, Transient
gRNA
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-PGK-Neo
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
- NCBI Accession:
- NM_008847
- Species:
- Mouse
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-PGK-Neo
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- U6 Promoter, PGK Promoter
- Expression:
- Stable, Transient
gRNA
PExp, GEEN
Lentiviral Vector
pLenti-U6-sgRNA-PGK-Neo
Ampicillin
U6 Promoter
unconjugated
Stable
- Type:
- gRNA
- Application:
- Protein Expression, Genome Editing with Engineered Nucleases
- Gene:
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
- NCBI Accession:
- NM_001135636
- Species:
- Human
- Vector type:
- Lentiviral Vector
- Vector backbone:
- pLenti-U6-sgRNA-PGK-Neo
- Resistance Gene:
- Ampicillin
- Selection Marker:
- Neomycin
- Promoter:
- U6 Promoter, PGK Promoter
- Expression:
- Stable, Transient
cDNA
Clon
Bacterial Expression Vector
pPB-His-GST
Kanamycin
T7 Promoter
His-GST
Transient
- Type:
- cDNA
- Application:
- Cloning
- Gene:
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
- Species:
- Human
- Vector type:
- Bacterial Expression Vector
- Vector backbone:
- pPB-His-GST
- Resistance Gene:
- Kanamycin
- Promoter:
- T7 Promoter
- Fusion Tag:
- His-GST
- Expression:
- Transient
cDNA
Clon
Bacterial Expression Vector
pPB-N-His
Kanamycin
T7 Promoter
His tag
Transient
- Type:
- cDNA
- Application:
- Cloning
- Gene:
- Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A)
- Species:
- Human
- Vector type:
- Bacterial Expression Vector
- Vector backbone:
- pPB-N-His
- Resistance Gene:
- Kanamycin
- Promoter:
- T7 Promoter
- Fusion Tag:
- His tag
- Expression:
- Transient
Synonyms and alternative names related to PIP5K1A
- phosphatidylinositol-4-phosphate 5-kinase type 1 alpha (PIP5K1A)
- phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha (Pip5k1a)
- phosphatidylinositol-4-phosphate 5-kinase, type I, alpha L homeolog (pip5k1a.L)
- phosphatidylinositol-4-phosphate 5-kinase, type I, alpha (pip5k1a)
- phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha (Pip5k1a)
- phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a (pip5k1aa)
- phosphatidylinositol-4-phosphate 5-kinase type 1 alpha (Pip5k1a)
- phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b (pip5k1ab)
- im:7140933
- PIP5K1A
- pip5k1a
- Pip5k1b
- pip5k1b
- pip5k1c
- Pipk5a
- Pipk5b
- zgc:110576
- zgc:158838
Gene-IDs for different species
Protein level used designations for PIP5K1A
- 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha
- 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha
- PIP5K1-alpha
- PIP5KIalpha
- phosphatidylinositol 4-phosphate 5-kinase type I alpha
- phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
- phosphatidylinositol-4-phosphate 5-kinase type-1 alpha
- ptdIns(4)P-5-kinase 1 alpha
- phosphatidylinositol-4-phosphate 5-kinase, type 1 beta
- phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
- phosphatidylinositol-4-phosphate 5-kinase, type I, beta
- 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase
- 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase
- PI4P5K-I[a]
- PI4P5KIbeta
- phosphatidylinositol 4-phosphate 5-kinase type I beta
- phosphatidylinositol-4-phosphate 5-kinase type I alpha
- phosphatidylinositol-4-phosphate 5-kinase type I beta
- phosphatidylinositol-4-phosphate 5-kinase type-1 gamma
Proteomics products related to PIP5K1A Gene
Other products related to PIP5K1A such as antibodies, ELISA kits and high-purity proteins are available on our partner website antibodies-online.com
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